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在吉兰丹哥打巴鲁苏丹后娜比雅二世医院登记的阿片类药物依赖者中,美沙酮维持治疗的有效性

The Effectiveness of Methadone Maintenance Therapy Among Opiate - Dependants Registered with Hospital Raja Perempuan Zainab II Kota Bharu, Kelantan.

作者信息

Premila Devi Jeganathan, Azriani Ab Rahman, Zahiruddin Wan Mohd, Mohd Ariff Mohd Noor, Noor Hashimah Abdullah

机构信息

Department of Community Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

出版信息

Malays J Med Sci. 2012 Oct;19(4):17-22.

Abstract

BACKGROUND

The objective of this study was to determine the effectiveness of MMT program among injecting drug users (IDUs) in Kota Bharu, Kelantan.

METHODS

The study was a retrospective study based on the records of injecting drug users (IDUs) involved in the MMT program from November 2005 to 31st Jan 2008, registered at the Psychiatric Clinic of Hospital Raja Perempuan Zainab II. Opiate Treatment Index (OTI) was used as the research instrument. Repeated measures ANCOVA was used to compare the mean scores during the entry period and after completing twelve months of MMT program after adjusted for age, marital status, and level of education.

RESULTS

A total of 117 file records were reviewed. There was significant reduction in the mean scores after 12 months of heroin Q score, HIV Risk-taking Behavior Scale and health scale after adjusted for age, marital status, and level of education. For Heroin Q score, mean difference was 2.01 (95% CI: 1.45, 2.56), for HIV Risk-taking Behavior Scale, mean difference was 7.64 (95% CI: 6.03, 9.26), and for health scale, mean difference was 5.35(95% CI: 3.90, 6.79).

CONCLUSION

This study supports the evidence that MMT program is effective in treating heroin and opiate dependence.

摘要

背景

本研究的目的是确定美沙酮维持治疗(MMT)项目在吉兰丹州哥打巴鲁的注射吸毒者中的有效性。

方法

本研究是一项回顾性研究,基于2005年11月至2008年1月31日在拉惹珀empuan再娜卜二世医院精神科诊所登记参与MMT项目的注射吸毒者记录。采用阿片类药物治疗指数(OTI)作为研究工具。在对年龄、婚姻状况和教育程度进行调整后,使用重复测量协方差分析来比较进入项目时和完成十二个月MMT项目后的平均得分。

结果

共审查了117份档案记录。在对年龄、婚姻状况和教育程度进行调整后,海洛因Q得分、HIV冒险行为量表得分和健康量表得分在12个月后均有显著降低。海洛因Q得分的平均差异为2.01(95%可信区间:1.45,2.56),HIV冒险行为量表得分的平均差异为7.64(95%可信区间:6.03,9.26),健康量表得分的平均差异为5.35(95%可信区间:3.90,6.79)。

结论

本研究支持MMT项目在治疗海洛因和阿片类药物依赖方面有效的证据。

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