Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Neonatology. 2013;104(1):15-21. doi: 10.1159/000348823. Epub 2013 Apr 23.
Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database.
The aim of this study was to analyse complications and outcome after implementation.
Data were retrieved from an online database to which all centres had contributed.
In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials.
The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials.
2008 年，荷兰和比利时佛兰德斯开始采用治疗性低温疗法。自此，接受治疗的患者数量不断增加，2010 年达到 166 例。并发症和预后情况被登记在一个在线数据库中。
本研究旨在分析实施治疗性低温疗法后的并发症和预后。
从一个在线数据库中检索数据，所有中心都向该数据库提供了数据。
3 年内共治疗了 332 例患者。排除 24 例存在先天性异常或代谢紊乱的患者，死亡率为 31.8%。210 例无先天性畸形的幸存者中，21 例患有脑瘫，另外 19 例在至少 24 个月时存在超过 3 个月的发育迟缓，2 例存在严重听力损失。在 308 例无先天性畸形的患者中，死亡和不良神经发育的总不良预后为 45.5%，与大型试验的结果相似。
在荷兰和佛兰德斯，对围产期窒息的新生儿快速成功地引入了治疗性低温疗法，结果与随机对照试验的结果相似。
