Englund E, Brun A
Department of Neuropathology, University Hospital, Lund, Sweden.
Histopathology. 1990 May;16(5):433-9. doi: 10.1111/j.1365-2559.1990.tb01542.x.
Structural white matter changes were found to be common in dementia of Alzheimer's type. A neuropathological investigation was undertaken in order to characterize and quantify these white matter changes. The tissue changes were compared with those in white matter in normal control cases and in complete white matter infarcts. Our results support the hypothesis that the white matter lesion seen in dementia of Alzheimer's type is due to incomplete infarction involving both axons and myelin and is a result of mild ischaemia. In mild ischaemia, the myelin compartment appears to be the most vulnerable. We have termed the lesion selective incomplete white matter infarction.
研究发现，阿尔茨海默病型痴呆中结构白质改变很常见。为了对这些白质改变进行特征描述和定量分析，开展了一项神经病理学研究。将组织变化与正常对照病例及完全性白质梗死病例的白质变化进行了比较。我们的结果支持这样一种假说，即阿尔茨海默病型痴呆中所见的白质病变是由于涉及轴突和髓鞘的不完全梗死，是轻度缺血的结果。在轻度缺血时，髓鞘部分似乎最易受损。我们将这种病变称为选择性不完全白质梗死。
