Ratnam K V, Phay K L, Tan C K
Department of Dermatology, National Skin Center, Kent Ridge, Singapore.
Int J Dermatol. 1990 Jun;29(5):363-7. doi: 10.1111/j.1365-4362.1990.tb04765.x.
Twenty-two newly diagnosed patients with pemphigus were randomly divided into two groups of 11 each. One group was placed on a high-dose prednisolone (120 mg/day) therapy and the other group on a low-dose (60 mg/day) therapy. The patients were followed for 5 years. Although a rapid initial control of the pemphigus appeared to be achieved with the high-dose regimen, this regimen did not have any long-term benefit over the low-dose regimen with respect to the frequency of relapse or in the incidence of complications.
22名新诊断的天疱疮患者被随机分为两组，每组11人。一组接受高剂量泼尼松龙（120毫克/天）治疗，另一组接受低剂量（60毫克/天）治疗。对患者进行了5年的随访。尽管高剂量方案似乎能迅速实现天疱疮的初始控制，但在复发频率或并发症发生率方面，该方案与低剂量方案相比没有任何长期益处。
