Division of Respirology, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.
BMC Pulm Med. 2013 Apr 24;13:24. doi: 10.1186/1471-2466-13-24.
There is little data on the effect of exercise on markers of airway inflammation in human asthmatics. The main objective of this review is to determine the effects of physical training on markers of airway inflammation in animal models of asthma.
A peer reviewed search was applied to Medline, Embase, Web of Science, Cochrane, and DARE databases. Data extraction was performed in a blinded fashion.
From the initial 2336 studies, a total of 10 studies were selected for the final analysis. All were randomized controlled trials with low to moderate intensity training on ovalbumin-sensitized mice. In the exercised group of mice, there was a reduction in BAL eosinophils and Th-2 cytokines, no change in Th-1 cytokines, an increase in IL-10, and a reversal of airway remodeling. The data was not pooled owing to significant heterogeneity between studies, and a funnel plot test for publication bias was not performed because there were few studies reporting on any one outcome measure. The asthma models differed between studies in age and gender of mice, as well as in timing of physical training after sensitization. The risk of bias was unclear for some studies though this may not influence outcome measures. The accuracy of data extracted from graphics is unknown.
Physical training improves airway inflammation in animal asthma models.
关于运动对人类哮喘患者气道炎症标志物的影响的数据很少。本综述的主要目的是确定体力训练对哮喘动物模型气道炎症标志物的影响。
应用同行评审搜索检索 Medline、Embase、Web of Science、Cochrane 和 DARE 数据库。以盲法进行数据提取。
从最初的 2336 项研究中，共有 10 项研究被纳入最终分析。所有研究均为随机对照试验，对卵清蛋白致敏的小鼠进行低至中等强度的训练。在锻炼组的小鼠中，BAL 嗜酸性粒细胞和 Th-2 细胞因子减少，Th-1 细胞因子无变化，IL-10 增加，气道重塑得到逆转。由于研究之间存在显著异质性，因此未对数据进行汇总，并且由于很少有研究报告任何一个结果测量，因此未进行漏斗图测试以评估发表偏倚。研究之间的哮喘模型在小鼠的年龄和性别以及致敏后体力训练的时间上存在差异。尽管这可能不会影响结果测量，但一些研究的偏倚风险尚不清楚。从图形中提取的数据的准确性未知。
体力训练可改善动物哮喘模型中的气道炎症。
