Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Neuroradiology. 2013 Jul;55(7):869-75. doi: 10.1007/s00234-013-1193-2. Epub 2013 Apr 26.
This study aimed to investigate whether the effect of scanner for cortex volumetry with atlas-based method is reduced using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) normalization compared with standard normalization.
Three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects were obtained and evaluated for effect of scanner in cortex volumetry. 3D-T1WIs of the 21 subjects were obtained with five MRI systems. Imaging of each subject was performed on each of five different MRI scanners. We used the Voxel-Based Morphometry 8 tool implemented in Statistical Parametric Mapping 8 and WFU PickAtlas software (Talairach brain atlas theory). The following software default settings were used as bilateral region-of-interest labels: "Frontal Lobe," "Hippocampus," "Occipital Lobe," "Orbital Gyrus," "Parietal Lobe," "Putamen," and "Temporal Lobe."
Effect of scanner for cortex volumetry using the atlas-based method was reduced with DARTEL normalization compared with standard normalization in Frontal Lobe, Occipital Lobe, Orbital Gyrus, Putamen, and Temporal Lobe; was the same in Hippocampus and Parietal Lobe; and showed no increase with DARTEL normalization for any region of interest (ROI).
DARTEL normalization reduces the effect of scanner, which is a major problem in multicenter studies.
本研究旨在探讨基于图谱的皮层容积分析方法中，使用弥散张量配准通过指数李代数（DARTEL）归一化是否比标准归一化减少了扫描仪的影响。
对 21 名健康受试者的三维 T1 加权磁共振图像（3D-T1WI）进行了获取和评估，以研究扫描仪对皮层容积的影响。21 名受试者的 3D-T1WI 通过 5 种 MRI 系统获取。每位受试者的成像在 5 种不同的 MRI 扫描仪上进行。我们使用了在统计参数映射 8 中实现的体素基于形态学 8 工具和 WFUPickAtlas 软件（Talairach 大脑图谱理论）。使用了以下软件默认设置作为双侧感兴趣区（ROI）标签：“额叶”、“海马体”、“枕叶”、“眶额回”、“顶叶”、“壳核”和“颞叶”。
与标准归一化相比，基于图谱的方法在使用 DARTEL 归一化后，额叶、枕叶、眶额回、壳核和颞叶的皮层容积扫描仪效应降低；在海马体和顶叶中则相同；在任何 ROI 中，DARTEL 归一化都没有增加效果。
DARTEL 归一化减少了扫描仪的影响，这是多中心研究中的一个主要问题。
