Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
J Digit Imaging. 2012 Feb;25(1):173-8. doi: 10.1007/s10278-011-9412-z.
The aims of this study were to (1) investigate the repeatability of measured volumes using the atlas-based method in each area of the brain, and (2) validate our hypothesis that the repeatability of the measured volumes with the atlas-based method was improved by using smoothed images. T1-weighted magnetic resonance images were obtained in five healthy subjects using the 1.5-T scanner. We used Statistical Parametric Mapping 5 and WFU PickAtlas software (theory of the Talairach brain atlas). Volumes inside region-of-interest (ROI) were measured in ten sets (five subjects × right and left) on six ROIs, respectively. One set comprises five images (one subject × five 3D-T1WIs). The percentage change was defined as [100 × (measured volume-mean volume in each set)/mean volume in each set)]. As a result, the average percentage changes using non-smoothed image on each ROI were as follows: gray matter, 0.482%; white matter, 0.375%; cerebrospinal fluid images, 0.731%; hippocampus, 0.864%; orbital gyrus, 1.692%; cerebellum posterior lobe, 0.854%. Using smoothed images with large FWHM resulted in improved repeatability on orbital gyrus. This is the first report of repeatability in each brain structure and improved repeatability with smoothed images using the atlas-based method.
(1) 调查基于图谱的方法在大脑各区域测量体积的可重复性；(2) 验证我们的假设，即使用平滑图像可提高基于图谱的方法测量体积的可重复性。使用 1.5-T 扫描仪对五名健康受试者进行 T1 加权磁共振成像。我们使用统计参数映射 5 和 WFU PickAtlas 软件（Talairach 大脑图谱理论）。在六个 ROI 中，分别在十个集（五个受试者×左右）中测量 ROI 内的体积。一个集包括五个图像（一个受试者×五个 3D-T1WI）。百分比变化定义为 [100×（测量体积-每个集的平均体积）/每个集的平均体积]。结果，每个 ROI 上使用非平滑图像的平均百分比变化如下：灰质，0.482%；白质，0.375%；脑脊液图像，0.731%；海马体，0.864%；眶回，1.692%；小脑后叶，0.854%。使用具有大 FWHM 的平滑图像可提高眶回的可重复性。这是首次报告基于图谱的方法在每个脑结构中的可重复性和使用平滑图像可提高可重复性。
