Nayak Chaturbhuja, Oberai Praveen, Varanasi Roja, Baig Hafeezullah, Ch Raveender, Reddy G R C, Devi Pratima, S Bhubaneshwari, Singh Vikram, Singh V P, Singh Hari, Shitanshu Shashi Shekhar
Central Council for Research in Homoeopathy, New Delhi, India.
Homeopathy. 2013 Apr;102(2):130-8. doi: 10.1016/j.homp.2013.02.004.
To evaluate homeopathic treatment in the management of diabetic distal symmetric polyneuropathy.
A prospective multi-centric clinical observational study was carried out from October 2005 to September 2009 by Central Council for Research in Homeopathy (CCRH) (India) at its five institutes/units. Patients suffering from diabetes mellitus (DM) and presenting with symptoms of diabetic polyneuropathy (DPN) were screened, investigated and were enrolled in the study after fulfilling the inclusion and exclusion criteria. Patients were evaluated by the diabetic distal symmetric polyneuropathy symptom score (DDSPSS) developed by the Council. A total of 15 homeopathic medicines were identified after repertorizing the nosological symptoms and signs of the disease. The appropriate constitutional medicine was selected and prescribed in 30, 200 and 1 M potency on an individualized basis. Patients were followed up regularly for 12 months.
Out of 336 patients (167 males and 169 females) enrolled in the study, 247 patients (123 males and 124 females) were analyzed. All patients who attended at least three follow-up appointments and baseline curve conduction studies were included in the analysis.). A statistically significant improvement in DDSPSS total score (p = 0.0001) was found at 12 months from baseline. Most objective measures did not show significant improvement. Lycopodium clavatum (n = 132), Phosphorus (n = 27) and Sulphur (n = 26) were the medicines most frequently prescribed. Adverse event of hypoglycaemia was observed in one patient only.
This study suggests homeopathic medicines may be effective in managing the symptoms of DPN patients. Further studies should be controlled and include the quality of life (QOL) assessment.
评估顺势疗法在糖尿病性远端对称性多发性神经病变管理中的作用。
2005年10月至2009年9月，印度顺势疗法中央研究理事会（CCRH）在其五个机构/单位开展了一项前瞻性多中心临床观察研究。对患有糖尿病（DM）且出现糖尿病性多发性神经病变（DPN）症状的患者进行筛选、检查，并在符合纳入和排除标准后纳入研究。通过该理事会制定的糖尿病远端对称性多发性神经病变症状评分（DDSPSS）对患者进行评估。在对该疾病的病症症状和体征进行辨证论治后，共确定了15种顺势疗法药物。根据个体情况选择合适的体质药物，并分别以30C、200C和1M的药力进行处方。对患者进行为期12个月的定期随访。
在纳入研究的336例患者（167例男性和169例女性）中，对247例患者（123例男性和124例女性）进行了分析。所有至少参加了三次随访预约和基线曲线传导研究的患者均纳入分析。与基线相比，12个月时DDSPSS总分有统计学意义的改善（p = 0.0001）。大多数客观指标未显示出显著改善。最常处方的药物是棒状石松（n = 132）、磷酸（n = 27）和硫磺（n = 26）。仅1例患者出现低血糖不良事件。
本研究表明顺势疗法药物可能对管理DPN患者的症状有效。进一步的研究应进行对照，并包括生活质量（QOL）评估。
