Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.
Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):2808-15. doi: 10.1016/j.msec.2013.03.011. Epub 2013 Mar 14.
This paper reports a new approach to fabricating biocompatible porous titanium with controlled pore structure and net-shape. The method is based on using sacrificial Mg particles as space holders to produce compacts that are mechanically stable and machinable. Using magnesium granules and Ti powder, Ti/Mg compacts with transverse rupture strength (~85 MPa) sufficient for machining were fabricated by warm compaction, and a complex-shape Ti scaffold was eventually produced by removal of Mg granules from the net-shape compact. The pores with the average size of 132-262 μm were well distributed and interconnected. Due to anisotropy and alignment of the pores the compressive strength varied with the direction of compression. In the case of pores aligned with the direction of compression, the compressive strength values (59-280 MPa) high enough for applications in load bearing implants were achieved. To verify the possibility of controlled net-shape, conventional machining process was performed on Ti/Mg compact. Compact with screw shape and porous Ti scaffold with hemispherical cup shape were fabricated by the results. Finally, it was demonstrated by cell tests using MC3T3-E1 cell line that the porous Ti scaffolds fabricated by this technique are biocompatible.
本文报道了一种新的方法来制造具有可控孔结构和净形状的生物相容性多孔钛。该方法基于使用牺牲 Mg 颗粒作为空间保持器来生产机械稳定和可加工的压坯。使用镁颗粒和 Ti 粉末，通过温压制备了具有足够横向断裂强度（约 85 MPa）以进行加工的 Ti/Mg 压坯，最终通过从净形状压坯中去除 Mg 颗粒来生产复杂形状的 Ti 支架。平均孔径为 132-262 μm 的孔分布均匀且相互连通。由于各向异性和孔的排列，压缩强度随压缩方向而变化。在与压缩方向对齐的孔的情况下，获得了足够高的压缩强度值（59-280 MPa），可用于承重植入物的应用。为了验证可控净形状的可能性，对 Ti/Mg 压坯进行了常规机械加工。通过该方法制备了具有螺旋形状的压坯和具有半球形杯形状的多孔 Ti 支架。最后，通过使用 MC3T3-E1 细胞系的细胞试验证明，通过该技术制造的多孔 Ti 支架具有生物相容性。
