Jung Hyun-Do, Lee Hyun, Kim Hyoun-Ee, Koh Young-Hag, Song Juha
Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology.
Department of Materials Science and Engineering, Seoul National University.
J Vis Exp. 2015 Dec 8(106):e53279. doi: 10.3791/53279.
Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.
生物金属系统已被广泛应用于生物医学领域，尤其是作为承重材料。然而，金属面临的主要挑战是高刚度和低生物活性。在本研究中，我们开发了一种制备新型生物活性和机械可靠性多孔金属支架——致密化多孔钛支架的新方法。该方法包括两个制造过程：1）通过动态冷冻铸造制备多孔钛支架；2）多孔支架的涂层和致密化。通过动态冷冻铸造制备多孔钛支架的方法，通过最小化化学污染和结构缺陷实现了多孔支架的致密化。致密化过程具有三个独特之处。首先，致密化过程简单，因为它只需要控制一个参数（致密化程度）。其次，它是有效的，因为它实现了机械增强和生物分子从多孔支架中的持续释放。第三，它具有广泛的应用，因为它还适用于在致密化过程中通过空间变化应变制造功能梯度多孔支架。
