• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多功能可生物降解的聚（丙烯酸）基水凝胶渗透到多孔钛植入物中以改善其生物功能性能。

Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance.

机构信息

Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville 41012, Spain.

Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, Seville 41012, Spain.

出版信息

Biomacromolecules. 2023 Nov 13;24(11):4743-4758. doi: 10.1021/acs.biomac.3c00532. Epub 2023 Sep 7.

DOI:10.1021/acs.biomac.3c00532
PMID:37677155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10646965/
Abstract

This research work proposes a synergistic approach to improve implants' performance through the use of porous Ti substrates to reduce the mismatch between Young's modulus of Ti (around 110 GPa) and the cortical bone (20-25 GPa), and the application of a biodegradable, acrylic acid-based polymeric coating to reduce bacterial adhesion and proliferation, and to enhance osseointegration. First, porous commercially pure Ti substrates with different porosities and pore size distributions were fabricated by using space-holder techniques to obtain substrates with improved tribomechanical behavior. On the other hand, a new diacrylate cross-linker containing a reduction-sensitive disulfide bond was synthesized to prepare biodegradable poly(acrylic acid)-based hydrogels with 1, 2, and 4% cross-linker. Finally, after the required characterization, both strategies were implemented, and the combination of 4% cross-linked poly(acrylic acid)-based hydrogel infiltrated in 30 vol % porosity, 100-200 μm average pore size, was revealed as an outstanding choice for enhancing implant performance.

摘要

本研究工作提出了一种协同方法，通过使用多孔 Ti 基底来改善植入物的性能，以减少 Ti（约 110GPa）与皮质骨（20-25GPa）之间的杨氏模量不匹配，以及应用可生物降解的、基于丙烯酸的聚合涂层来减少细菌黏附和增殖，并增强骨整合。首先，使用空间占位技术制造了具有不同孔隙率和孔径分布的多孔商用纯 Ti 基底，以获得具有改善摩擦学性能的基底。另一方面，合成了一种含有还原敏感二硫键的新型二丙烯酸酯交联剂，以制备具有 1%、2%和 4%交联剂的可生物降解的聚（丙烯酸）基水凝胶。最后，在进行了所需的表征后，实施了这两种策略，结果表明，4%交联的聚（丙烯酸）基水凝胶在 30vol%孔隙率、100-200μm 平均孔径下的渗透是增强植入物性能的绝佳选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/ec1e9295ea1d/bm3c00532_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/33fd2e27e06b/bm3c00532_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/df862dfc2409/bm3c00532_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/47227a1a515b/bm3c00532_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/5930b6e79320/bm3c00532_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/f1ad0e3e3377/bm3c00532_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/06e9dddc8325/bm3c00532_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/8d5095518897/bm3c00532_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/a4c94a473cf9/bm3c00532_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/43cb7a962224/bm3c00532_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/42e301b945ac/bm3c00532_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/ec1e9295ea1d/bm3c00532_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/33fd2e27e06b/bm3c00532_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/df862dfc2409/bm3c00532_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/47227a1a515b/bm3c00532_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/5930b6e79320/bm3c00532_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/f1ad0e3e3377/bm3c00532_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/06e9dddc8325/bm3c00532_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/8d5095518897/bm3c00532_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/a4c94a473cf9/bm3c00532_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/43cb7a962224/bm3c00532_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/42e301b945ac/bm3c00532_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d9/10646965/ec1e9295ea1d/bm3c00532_0011.jpg

相似文献

1
Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance.多功能可生物降解的聚（丙烯酸）基水凝胶渗透到多孔钛植入物中以改善其生物功能性能。
Biomacromolecules. 2023 Nov 13;24(11):4743-4758. doi: 10.1021/acs.biomac.3c00532. Epub 2023 Sep 7.
2
Biofunctional and Tribomechanical Behavior of Porous Titanium Substrates Coated with a Bioactive Glass Bilayer (45S5-1393).具有生物活性双层玻璃（45S5-1393）涂层的多孔钛基底的生物功能和摩擦学性能。
ACS Appl Mater Interfaces. 2020 Jul 8;12(27):30170-30180. doi: 10.1021/acsami.0c07318. Epub 2020 Jun 25.
3
Osseointegration of 3D porous and solid Ti-6Al-4V implants - Narrow gap push-out testing and experimental setup considerations.3D多孔和实心Ti-6Al-4V植入物的骨整合——窄间隙推出测试及实验装置考量
J Mech Behav Biomed Mater. 2021 Mar;115:104282. doi: 10.1016/j.jmbbm.2020.104282. Epub 2020 Dec 14.
4
Effects of pore size and porosity on cytocompatibility and osteogenic differentiation of porous titanium.孔径和孔隙率对多孔钛细胞相容性和成骨分化的影响。
J Mater Sci Mater Med. 2021 Jun 14;32(6):72. doi: 10.1007/s10856-021-06548-0.
5
Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.多孔钛基体上生物活性明胶-海藻酸钠-生物活性玻璃复合涂层的制备与表征。
ACS Appl Mater Interfaces. 2022 Apr 6;14(13):15008-15020. doi: 10.1021/acsami.2c01241. Epub 2022 Mar 22.
6
Fabrication, pore structure and compressive behavior of anisotropic porous titanium for human trabecular bone implant applications.用于人体小梁骨植入应用的各向异性多孔钛的制备、孔隙结构及压缩行为
J Mech Behav Biomed Mater. 2015 Jun;46:104-14. doi: 10.1016/j.jmbbm.2015.02.023. Epub 2015 Mar 3.
7
Osteoconductivity of bioactive Ti-6Al-4V implants with lattice-shaped interconnected large pores fabricated by electron beam melting.通过电子束熔炼制造的具有晶格状相互连接大孔的生物活性Ti-6Al-4V植入物的骨传导性。
J Biomater Appl. 2021 Apr;35(9):1153-1167. doi: 10.1177/0885328220968218. Epub 2020 Oct 26.
8
Porous titanium-6 aluminum-4 vanadium cage has better osseointegration and less micromotion than a poly-ether-ether-ketone cage in sheep vertebral fusion.多孔钛-6 铝-4 钒笼在羊的椎体融合中比聚醚醚酮笼具有更好的骨整合和更小的微动。
Artif Organs. 2013 Dec;37(12):E191-201. doi: 10.1111/aor.12153. Epub 2013 Oct 22.
9
Cancellous bone from porous Ti6Al4V by multiple coating technique.通过多重涂层技术从多孔Ti6Al4V获得的松质骨。
J Mater Sci Mater Med. 2006 Feb;17(2):179-85. doi: 10.1007/s10856-006-6822-4.
10
Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications.用于生物医学应用的新型多孔 Ti6Al4V 植入物的仿生机械设计和 3D 打印。
J Zhejiang Univ Sci B. 2019;20(8):647-659. doi: 10.1631/jzus.B1800622.

引用本文的文献

1
Composite Contrast Enhancement of Hydrogel-Based Implants for Photon-Counting Computed Tomography Studies.用于光子计数计算机断层扫描研究的水凝胶基植入物的复合对比增强
Gels. 2024 Dec 8;10(12):807. doi: 10.3390/gels10120807.
2
Polymyxin B Peptide Hydrogel Coating: A Novel Approach to Prevent Ventilator-Associated Pneumonia.多粘菌素 B 肽水凝胶涂层：预防呼吸机相关性肺炎的新方法。
Int J Mol Sci. 2024 Sep 24;25(19):10269. doi: 10.3390/ijms251910269.
3
Design approaches for 3D cell culture and 3D bioprinting platforms.3D细胞培养和3D生物打印平台的设计方法。

本文引用的文献

1
Electrical Potentiometry with Intraoral Applications.口腔内应用的电位测定法。
Materials (Basel). 2022 Jul 22;15(15):5100. doi: 10.3390/ma15155100.
2
Antimicrobial Properties of Amino-Acid-Derived N-Heterocyclic Carbene Silver Complexes.氨基酸衍生的 N-杂环卡宾银配合物的抗菌性能
Pharmaceutics. 2022 Mar 30;14(4):748. doi: 10.3390/pharmaceutics14040748.
3
Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications.聚丙烯酸纳米平台：抗菌、组织工程及癌症诊疗应用
Biophys Rev (Melville). 2024 May 16;5(2):021304. doi: 10.1063/5.0188268. eCollection 2024 Jun.
Polymers (Basel). 2022 Mar 21;14(6):1259. doi: 10.3390/polym14061259.
4
Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.多孔钛基体上生物活性明胶-海藻酸钠-生物活性玻璃复合涂层的制备与表征。
ACS Appl Mater Interfaces. 2022 Apr 6;14(13):15008-15020. doi: 10.1021/acsami.2c01241. Epub 2022 Mar 22.
5
Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance.天然和复合水凝胶作为限制抗生素耐药性的有前景材料。
Gels. 2022 Jan 20;8(2):70. doi: 10.3390/gels8020070.
6
Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing.具有抗菌活性的自修复多糖基可注射水凝胶用于伤口愈合。
Carbohydr Polym. 2022 Jan 1;275:118770. doi: 10.1016/j.carbpol.2021.118770. Epub 2021 Oct 17.
7
Carboxymethyl cellulose/tetracycline@UiO-66 nanocomposite hydrogel films as a potential antibacterial wound dressing.羧甲基纤维素/四环素@UiO-66 纳米复合水凝胶膜作为一种有潜力的抗菌伤口敷料。
Int J Biol Macromol. 2021 Oct 1;188:811-819. doi: 10.1016/j.ijbiomac.2021.08.061. Epub 2021 Aug 11.
8
Alternatives to Conventional Antibiotic Therapy: Potential Therapeutic Strategies of Combating Antimicrobial-Resistance and Biofilm-Related Infections.替代传统抗生素治疗：对抗抗微生物耐药性和生物膜相关感染的潜在治疗策略。
Mol Biotechnol. 2021 Dec;63(12):1103-1124. doi: 10.1007/s12033-021-00371-2. Epub 2021 Jul 26.
9
Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.羟基磷灰石涂层对颅骨植入物有益的骨整合效果 - FEM 研究。
PLoS One. 2021 Jul 19;16(7):e0254837. doi: 10.1371/journal.pone.0254837. eCollection 2021.
10
The unfavorable role of titanium particles released from dental implants.种植体释放的钛颗粒的不良作用。
Nanotheranostics. 2021 Mar 10;5(3):321-332. doi: 10.7150/ntno.56401. eCollection 2021.