Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois.
Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, Illinois.
J Am Coll Cardiol. 2013 Jul 16;62(3):201-207. doi: 10.1016/j.jacc.2013.03.049. Epub 2013 Apr 23.
The aim of this study was to assess whether young binge drinkers (BD) have impaired macrovascular and microvascular function and cardiovascular disease risk factors compared with age-matched alcohol abstainers (A).
Binge drinking rates are highest on college campuses and among those age 18 to 25 years; however, macrovascular and microvascular endothelial function in young adults with histories of repeated binge drinking (≥ 5 standard drinks in 2 h in men, ≥ 4 standard drinks in 2 h in women) has not been investigated.
Cardiovascular profiles, brachial artery endothelial-dependent flow-mediated dilation (FMD), and flow-independent nitroglycerin (NTG)-mediated dilation and vasoreactivity of resistance arteries (isolated from gluteal fat biopsies) were evaluated in A and BD.
Men and women (18 to 25 years of age; A, n = 17; BD, n = 19) were enrolled. In the BD group, past-month mean number of binge episodes was 6 ± 1, and the mean duration of binge drinking behavior was 4 ± 0.6 years. FMD and NTG-mediated dilation were significantly lower in the BD group (FMD: 8.4 ± 0.7%, p = 0.022; NTG-mediated dilation: 19.6 ± 2%, p = 0.009) than in the A group (FMD: 11 ± 0.7%; NTG-mediated dilation: 28.6 ± 2%). Acetylcholine-induced and sodium nitroprusside-induced dilation in resistance arteries was not significantly different between the A and BD groups. However, endothelin-1-induced constriction was significantly enhanced in the BD group compared with the A group (p = 0.032). No differences between groups were found in blood pressure, lipoproteins, and C-reactive protein.
Alterations in the macrocirculation and microcirculation may represent early clinical manifestations of cardiovascular risk in otherwise healthy young BD. This study has important clinical implications for screening young adults for a repeated history of binge drinking.
本研究旨在评估与年龄匹配的戒酒者（A）相比，年轻的 binge drinkers（BD）是否存在大血管和微血管功能以及心血管疾病危险因素受损的情况。
大学校园和 18 至 25 岁年龄段的 binge drinking 率最高；然而，对于有过反复 binge drinking（男性 2 小时内≥ 5 标准杯，女性 2 小时内≥ 4 标准杯）史的年轻成年人的大血管和微血管内皮功能尚未进行研究。
评估 A 和 BD 人群的心血管特征、肱动脉内皮依赖性血流介导的扩张（FMD）以及非依赖性硝普盐（NTG）介导的扩张和阻力血管的血管反应性（从臀脂活检中分离出来）。
纳入了 18 至 25 岁的男性和女性（A 组，n = 17；BD 组，n = 19）。BD 组中，过去一个月的 binge 发作平均次数为 6 ± 1，binge drinking 行为的平均持续时间为 4 ± 0.6 年。BD 组的 FMD 和 NTG 介导的扩张明显低于 A 组（FMD：8.4 ± 0.7%，p = 0.022；NTG 介导的扩张：19.6 ± 2%，p = 0.009）。A 组和 BD 组之间，乙酰胆碱诱导和硝普钠诱导的阻力血管扩张没有显著差异。然而，BD 组的内皮素-1诱导的收缩明显强于 A 组（p = 0.032）。两组间的血压、脂蛋白和 C 反应蛋白没有差异。
大循环和微循环的改变可能代表了 otherwise healthy 的年轻 BD 人群心血管风险的早期临床表现。本研究对筛查年轻成年人反复 binge drinking 史具有重要的临床意义。
