Rotman Research Institute, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada.
Horm Behav. 2013 Jul;64(2):195-202. doi: 10.1016/j.yhbeh.2013.04.004. Epub 2013 Apr 23.
This article is part of a Special Issue "Puberty and Adolescence". This review provides a conceptual framework for the study of factors--in our genes and environment--that shape the adolescent brain. I start by pointing out that brain phenotypes obtained with magnetic resonance imaging are complex traits reflecting the interplay of genes and the environment. In some cases, variations in the structural phenotypes observed during adolescence have their origin in the pre-natal or early post-natal periods. I then emphasize the bidirectional nature of brain-behavior relationships observed during this period of human development, where function may be more likely to influence structure rather than vice versa. In the main part of this article, I review our ongoing work on the influence of gonadal hormones on the adolescent brain. I also discuss the importance of social context and brain plasticity on shaping the relevant neural circuits.
这篇文章是“青春期”特刊的一部分。这篇综述为研究影响青少年大脑的因素提供了一个概念框架，这些因素存在于我们的基因和环境中。我首先指出，使用磁共振成像获得的脑表型是反映基因和环境相互作用的复杂特征。在某些情况下，青少年时期观察到的结构表型的变化起源于产前或出生后早期。然后我强调了在人类发育的这个时期观察到的脑-行为关系的双向性，在这个时期，功能更有可能影响结构，而不是相反。在本文的主要部分，我回顾了我们正在进行的关于性腺激素对青少年大脑影响的研究。我还讨论了社会环境和大脑可塑性对塑造相关神经回路的重要性。
