Long Sara-Jayne, Benton David
Department of Psychology, University of Swansea, Swansea, Wales, UK.
Hum Psychopharmacol. 2013 May;28(3):238-47. doi: 10.1002/hup.2313. Epub 2013 Apr 29.
Although a series of well-designed studies have reported that supplementation with vitamins/minerals and omega-3 fatty acids reduces the incidence of aggressive behavior, to date, the relative contribution and interaction between these nutrients has not been examined. The aim was therefore to consider the relative contribution of supplementation with multivitamins/minerals and/or docosahexaenoic acid (DHA) on laboratory-based measures of aggression, impulsivity, and stress.
In a double-blind randomized trial, four groups of young adult men without a history of aggressive or impulsive behavior received a placebo (n = 42), multivitamins/minerals (n = 43), DHA (n = 47) or both (n = 41) for 3 months.
With the Picture-Frustration Task, DHA decreased the display of aggressive behavior. DHA also decreased impulsivity as measured using the GoStop Impulsivity Paradigm that examines the ability to inhibit already initiated behavior. Although a multivitamin and mineral supplement did not influence these measures, it did decrease perceived stress.
The influence of supplementation on aggression and impulsivity can be conveniently studied in a sample without a history of antisocial behavior, using laboratory-based measures. No evidence was found of a synergistic interaction between vitamins/minerals and DHA.
尽管一系列精心设计的研究报告称，补充维生素/矿物质和ω-3脂肪酸可降低攻击性行为的发生率，但迄今为止，尚未对这些营养素之间的相对贡献和相互作用进行研究。因此，本研究旨在探讨补充多种维生素/矿物质和/或二十二碳六烯酸（DHA）对基于实验室的攻击性、冲动性和应激指标的相对贡献。
在一项双盲随机试验中，四组无攻击或冲动行为史的年轻成年男性分别接受安慰剂（n = 42）、多种维生素/矿物质（n = 43）、DHA（n = 47）或两者（n = 41），为期3个月。
在图片挫折任务中，DHA减少了攻击行为的表现。DHA还降低了使用GoStop冲动范式测量的冲动性，该范式用于考察抑制已启动行为的能力。虽然多种维生素和矿物质补充剂对这些指标没有影响，但它确实降低了感知到的压力。
使用基于实验室的测量方法，可以在无反社会行为史的样本中方便地研究补充剂对攻击性和冲动性的影响。未发现维生素/矿物质与DHA之间存在协同相互作用的证据。
