Department of Anatomy, University of Kiel, 24098 Kiel, Germany.
J Neuroimmunol. 2013 Jul 15;260(1-2):47-54. doi: 10.1016/j.jneuroim.2013.04.006. Epub 2013 Apr 28.
Since chemokines and their receptors play a pivotal role in tumors, we investigated the CXCL16-CXCR6-axis in human astroglial tumors. The transmembrane chemokine CXCL16 is heavily expressed by tumor, microglial and endothelial cells in situ and in vitro. In contrast, the receptor CXCR6 is restricted in glioblastomas to a small subset of proliferating cells positive for the stem-cell markers Musashi, Nanog, Sox2 and Oct4. In particular, the vast majority (about 90%) of Musashi-positive cells stained also for CXCR6. Thus, CXCL16 is highly expressed by glial tumor and stroma cells whereas CXCR6 defines a subset of cells with stem cell character.
由于趋化因子及其受体在肿瘤中起着关键作用，我们研究了人星形胶质细胞瘤中的 CXCL16-CXCR6 轴。跨膜趋化因子 CXCL16 在肿瘤、小胶质细胞和内皮细胞原位和体外均高度表达。相比之下，受体 CXCR6 在胶质母细胞瘤中仅限于一小部分表达干细胞标志物 Musashi、Nanog、Sox2 和 Oct4 的增殖细胞。特别是，绝大多数（约 90%） Musashi 阳性细胞也染色为 CXCR6。因此，CXCL16 由神经胶质肿瘤和基质细胞高度表达，而 CXCR6 则定义了具有干细胞特征的细胞亚群。
