Zhu Wenting, Nelson Celeste M
Department of Chemical and Biological Engineering; Princeton University; Princeton, NJ USA.
Department of Chemical and Biological Engineering; Princeton University; Princeton, NJ USA; Department of Molecular Biology; Princeton University; Princeton, NJ USA.
Biomatter. 2013 Jul-Sep;3(3). doi: 10.4161/biom.24630. Epub 2013 Apr 1.
Breast reconstruction is a type of surgery for women who have had a mastectomy, and involves using autologous tissue or prosthetic material to construct a natural-looking breast. Adipose tissue is the major contributor to the volume of the breast, whereas epithelial cells comprise the functional unit of the mammary gland. Adipose-derived stem cells (ASCs) can differentiate into both adipocytes and epithelial cells and can be acquired from autologous sources. ASCs are therefore an attractive candidate for clinical applications to repair or regenerate the breast. Here we review the current state of adipose tissue engineering methods, including the biomaterials used for adipose tissue engineering and the application of these techniques for mammary epithelial tissue engineering. Adipose tissue engineering combined with microfabrication approaches to engineer the epithelium represents a promising avenue to replicate the native structure of the breast.
乳房重建是一种针对接受过乳房切除术的女性的手术，涉及使用自体组织或假体材料构建外观自然的乳房。脂肪组织是乳房体积的主要组成部分，而上皮细胞构成乳腺的功能单位。脂肪来源干细胞（ASC）可分化为脂肪细胞和上皮细胞，且可从自体获取。因此，ASC是乳房修复或再生临床应用中颇具吸引力的候选对象。在此，我们综述脂肪组织工程方法的现状，包括用于脂肪组织工程的生物材料以及这些技术在乳腺上皮组织工程中的应用。脂肪组织工程与微制造方法相结合以构建上皮组织，是复制乳房天然结构的一条有前景的途径。
