Paillère Martinot M-L, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker G J, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins T W, Smolka M N, Schumann G, Martinot J-L
1] AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [4] Université Paris-Sud 11, Orsay, France.
1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France.
Mol Psychiatry. 2014 Apr;19(4):462-70. doi: 10.1038/mp.2013.44. Epub 2013 Apr 30.
Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those alterations would be associated with differences in gray-matter (GM) volumes. Forty-two adolescents with three core manic symptoms and no psychiatric diagnosis, and 126 adolescents matched by age and sex, with no psychiatric diagnosis or symptoms, were identified after screening the IMAGEN database of 2223 young adolescents recruited from the general population. After image quality control, voxel-wise statistics were performed on the diffusion parameters using tract-based spatial statistics in 25 SBP adolescents and 77 controls, and on GM and WM images using voxel-based morphometry in 30 SBP adolescents and 106 controls. As compared with healthy controls, adolescents with SBP displayed lower FA values in a number of WM tracts, particularly in the corpus callosum, cingulum, bilateral superior and inferior longitudinal fasciculi, uncinate fasciculi and corticospinal tracts. Radial diffusivity was mainly higher in posterior parts of bilateral superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculi and right cingulum. As compared with controls, SBP adolescents had lower GM volume in the left anterior cingulate region. This is the first study to investigate WM microstructure and GM morphometric variations in adolescents with SBP. The widespread FA alterations in association and projection tracts, associated with GM changes in regions involved in mood disorders, suggest altered structural connectivity in those adolescents.
在青少年期起病的双相情感障碍患者以及有双相情感障碍家族风险的青少年中，已报告存在白质（WM）微观结构异常，如分数各向异性（FA）降低。我们试图确定有阈下双相症状（SBP）的健康青少年是否会有早期WM微观结构改变，以及这些改变是否与灰质（GM）体积差异有关。在对从普通人群中招募的2223名青少年的IMAGEN数据库进行筛查后，确定了42名有三种核心躁狂症状且无精神疾病诊断的青少年，以及126名按年龄和性别匹配、无精神疾病诊断或症状的青少年。图像质量控制后，对25名SBP青少年和77名对照者的扩散参数使用基于束的空间统计学进行体素级统计，对30名SBP青少年和106名对照者的GM和WM图像使用基于体素的形态计量学进行统计。与健康对照相比，SBP青少年在多个WM束中显示出较低的FA值，特别是在胼胝体、扣带束、双侧上纵束和下纵束、钩束和皮质脊髓束中。径向扩散率主要在双侧上纵束和下纵束的后部、额枕下束和右侧扣带束中较高。与对照相比，SBP青少年左前扣带区的GM体积较低。这是第一项研究有SBP的青少年的WM微观结构和GM形态计量学变化的研究。联合束和投射束中广泛的FA改变，与情绪障碍相关区域的GM变化相关，提示这些青少年的结构连接性改变。
