Panin L E, Atuchina N V, Tret'iakova T A
Probl Endokrinol (Mosk). 1990 Mar-Apr;36(2):83-6.
The authors described a cooperative effect of glucocorticoids, catecholamines and high density lipoproteins (HDLP), based on increased hexokinase and glucokinase biosynthesis in the liver, resulting in elevated activity of the respective enzymes. This effect was completely blocked by actinomycin-D (a DNA-dependent inhibitor of RNA synthesis), vinblastine (an inhibitor of the microtubular apparatus and intracellular shift) and gordox (an inhibitor of serine proteinases). The modulating effect of HDLP with relation to the adaptive hormones emphasizes the cooperative nature of the new mechanism of enzymatic synthesis induction.
作者描述了糖皮质激素、儿茶酚胺和高密度脂蛋白（HDLP）的协同作用，其基础是肝脏中己糖激酶和葡萄糖激酶生物合成增加，导致相应酶的活性升高。放线菌素 -D（一种依赖DNA的RNA合成抑制剂）、长春碱（一种微管装置和细胞内转运抑制剂）和抑肽酶（一种丝氨酸蛋白酶抑制剂）可完全阻断这种作用。HDLP对适应性激素的调节作用强调了酶合成诱导新机制的协同性质。
