Panin L E, Filatova T G
Probl Endokrinol (Mosk). 1986 Jul-Aug;32(4):69-71.
The role of adaptive hormones and serum lipoproteins in the regulation of glucose-6-phosphate dehydrogenase (G-6-PDH) activity was investigated. The test was performed on experimental hepatic sections of Wistar rats. It was shown that timely regulation of G-6-PDH by epinephrine and hydrocortisone which inhibits the activity of enzyme is manifested through the cAMP-dependent mechanism. The cooperative effect of epinephrine, hydrocortisone and high-density lipoproteins that enables G-6-PDH activation was revealed. It was stated that only high-density lipoproteins of subpopulation III were capable of hormonal mediating. The effect was caused by the induction of enzyme synthesis and manifested through lysosome-dependent activation of chromatin.
研究了适应性激素和血清脂蛋白在调节葡萄糖-6-磷酸脱氢酶（G-6-PDH）活性中的作用。该试验在Wistar大鼠的实验性肝切片上进行。结果表明，肾上腺素和氢化可的松对G-6-PDH的及时调节（抑制该酶的活性）是通过cAMP依赖性机制表现出来的。还揭示了肾上腺素、氢化可的松和高密度脂蛋白的协同作用可激活G-6-PDH。据指出，只有亚群III的高密度脂蛋白能够介导激素作用。这种作用是由酶合成的诱导引起的，并通过溶酶体依赖性的染色质激活表现出来。
