Department of Obstetrics and Prenatal Medicine, University Medical School Bonn, Bonn, Germany.
Prenat Diagn. 2013 Aug;33(8):722-5. doi: 10.1002/pd.4107. Epub 2013 Apr 29.
Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies.
Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM).
In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin-to-twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter-twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71).
Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction.
辅助生殖技术（ART）治疗的双胞胎的颈项透明层（NT）测量研究较少。因此，本研究比较了双绒毛膜（DC）和单绒毛膜（MC）妊娠中自然受孕的双胞胎和 ART 双胞胎的 NT 测量值。
回顾性分析了 11+0 至 13+6 周期间的 706 例未受影响的双胞胎，这些双胞胎分别为自然受孕（n=362）或通过 ART 受孕（n=344）。自然受孕组包括 234 例 DC（64.6%）和 128 例 MC（35.4%）妊娠。在 ART 组中，326 例为 DC（94.7%），18 例为 MC（5.3%）。NT 值转换为中位数倍数（MoM）。
在 DC 组中，ART 和自然受孕的双胞胎之间没有显著差异（NT MoM 1.06±0.28 与 1.03±0.29；p>0.05）。与自然受孕的 MC 双胞胎相比，MC ART 双胞胎的 NT MoM 更高（1.23±0.82 与 0.99±0.27；p=0.011）。尽管 ART 双胞胎的双胎输血综合征（TTTS）发生率较高（11.1% vs 4.7%），但 TTTS （0.42±0.21）或无 TTTS （0.40±0.71）妊娠的双胞胎之间的 NT 差值相似。
在 DC ART 双胞胎中测量 NT 厚度可获得与自然受孕双胞胎相当的结果。MC 双胞胎的结论有限；然而，较高的 NT MoM 与 TTTS 或选择性宫内生长受限无关。
