细胞色素 p450：疾病中的作用。
Cytochromes p450: roles in diseases.
机构信息
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
J Biol Chem. 2013 Jun 14;288(24):17091-8. doi: 10.1074/jbc.R112.431916. Epub 2013 Apr 30.
Abstract
The cytochrome P450 superfamily consists of a large number of heme-containing monooxygenases. Many human P450s metabolize drugs used to treat human diseases. Others are necessary for synthesis of endogenous compounds essential for human physiology. In some instances, alterations in specific P450s affect the biological processes that they mediate and lead to a disease. In this minireview, we describe medically significant human P450s (from families 2, 4, 7, 11, 17, 19, 21, 24, 27, 46, and 51) and the diseases associated with these P450s.
摘要
细胞色素 P450 超家族由大量含有血红素的单加氧酶组成。许多人 P450 代谢用于治疗人类疾病的药物。其他则是合成内源性化合物所必需的，这些化合物对人体生理学至关重要。在某些情况下，特定 P450 的改变会影响它们介导的生物过程，并导致疾病。在这篇小综述中，我们描述了具有医学意义的人 P450（来自家族 2、4、7、11、17、19、21、24、27、46 和 51）以及与这些 P450 相关的疾病。
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