*Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam †Department of Internal Medicine, Chonnam National University Medical School, Gwangju ‡Department of Internal Medicine, Hallym University College of Medicine, Chuncheon §Department of Internal Medicine, Dankook University College of Medicine, Cheonan ∥Department of Internal Medicine, Wonkwang University College of Medicine, Iksan ¶Department of Internal Medicine, Pusan National University School of Medicine, Busan #Department of Internal Medicine, Jeju National University School of Medicine, Jeju **School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
J Clin Gastroenterol. 2014 Feb;48(2):e12-8. doi: 10.1097/MCG.0b013e31828f4bc9.
To evaluate the prevalence of functional dyspepsia (FD) and its risk factors.
FD is a common disorder, but its negative influences greatly affect the quality of life. The predictive factors of FD are still ambiguous.
A total of 3399 participants underwent screening gastroscopy at one of 7 nationwide health care centers in Korea and who completed a questionnaire. Atrophic gastritis was defined by gastroscopy. Serologic Helicobacter pylori immunoglobulin G antibody was measured by enzyme-linked immunosorbent assay.
Of the 3399 participants who did not have organic diseases, 694 (20.4%) had dyspeptic symptoms such as epigastric pain/soreness or postprandial discomfort. Among the 694 participants, atrophic gastritis and positive H. pylori serology were found in 282 (40.6%) and 422 (60.8%), respectively; these proportions were not different from the remaining asymptomatic subjects. Multivariate analysis showed that having relatives with gastric cancer [odds ratio (OR), 1.35; 95% confidence interval (CI), 1.01-1.81], education below college (OR, 1.32; 95% CI, 1.06-1.64), and high-salt diet (OR, 1.33; 95% CI, 1.05-1.68) were associated with FD symptoms.
FD symptoms were frequently found in the health check-up subjects. Relatives of gastric cancer, education below college, and high-salt diet were risk factors of FD, suggesting that FD is a multifactorial disease.
评估功能性消化不良（FD）的患病率及其危险因素。
FD 是一种常见疾病，但它的负面影响极大地影响了生活质量。FD 的预测因素仍不清楚。
共有 3399 名参与者在韩国的 7 家全国性医疗保健中心中的一家接受了筛查性胃镜检查，并完成了一份问卷。萎缩性胃炎通过胃镜检查定义。血清幽门螺杆菌免疫球蛋白 G 抗体通过酶联免疫吸附试验测量。
在 3399 名没有器质性疾病的参与者中，有 694 名（20.4%）有消化不良症状，如上腹痛/疼痛或餐后不适。在 694 名有症状的参与者中，分别有 282 名（40.6%）和 422 名（60.8%）存在萎缩性胃炎和 H. pylori 血清学阳性；这些比例与无症状的其余受试者没有差异。多变量分析显示，有胃癌亲属（比值比 [OR]，1.35；95%置信区间 [CI]，1.01-1.81）、受教育程度低于大学（OR，1.32；95% CI，1.06-1.64）和高盐饮食（OR，1.33；95% CI，1.05-1.68）与 FD 症状相关。
在健康检查参与者中经常发现 FD 症状。胃癌亲属、受教育程度低于大学和高盐饮食是 FD 的危险因素，提示 FD 是一种多因素疾病。
