Asano Haruki, Tomita Toshihiko, Nakamura Kumiko, Yamasaki Takahisa, Okugawa Takuya, Kondo Takashi, Kono Tomoaki, Tozawa Katsuyuki, Ohda Yoshio, Oshima Tadayuki, Fukui Hirokazu, Fukushima Kazuhito, Hirota Shozo, Watari Jiro, Miwa Hiroto
Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Division of Nuclear Medicine and PET Center, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
J Neurogastroenterol Motil. 2017 Jul 30;23(3):392-399. doi: 10.5056/jnm16173.
BACKGROUND/AIMS: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD.
Forty healthy subjects and 94 PDS type FD patients were enrolled in the study. The volunteers and patients ingested a radiolabeled (technetium-99m) solid test meal, and scintigraphic images were recorded. Gastric accommodation and emptying were assessed by scintigraphic imaging. The patients' dyspeptic symptoms were also explored using self-completed symptom questionnaires with 10 variables (4 scales, 0-3 points) at the same time.
In 94 Japanese FD patients, the prevalence of impaired gastric accommodation and delayed emptying were 14.9% (14/94) and 10.6% (10/94), respectively. Gastric motility abnormalities were seen in 25.5% (24/94) of FD patients. There was no association between gastric motility abnormalities and dyspeptic symptoms.
Gastric motility abnormalities were seen in 25.5% of Japanese PDS type FD patients. However, there was no association between gastric motility abnormalities and dyspeptic symptoms on gastric scintigraphy.
背景/目的：胃动力异常被认为是功能性消化不良（FD）的病理生理特征，与消化不良症状密切相关，尤其是餐后不适综合征（PDS）。本研究的目的是：（1）调查胃动力障碍的患病率；（2）使用胃闪烁扫描评估PDS型FD患者胃动力异常与消化不良症状之间的关联。
本研究纳入了40名健康受试者和94名PDS型FD患者。志愿者和患者摄入放射性标记（锝-99m）的固体试验餐，并记录闪烁扫描图像。通过闪烁扫描成像评估胃容纳和排空情况。同时，使用包含10个变量（4个量表，0 - 3分）的自我完成症状问卷对患者的消化不良症状进行调查。
在94名日本FD患者中，胃容纳受损和排空延迟的患病率分别为14.9%（14/94）和10.6%（10/94）。25.5%（24/94）的FD患者存在胃动力异常。胃动力异常与消化不良症状之间无关联。
25.5%的日本PDS型FD患者存在胃动力异常。然而，胃闪烁扫描显示胃动力异常与消化不良症状之间无关联。
