Kim Sung Eun, Kim Nayoung, Lee Ju Yup, Park Kyung Sik, Shin Jeong Eun, Nam Kwangwoo, Kim Hyeon Ju, Song Hyun Joo, Joo Young-Eun, Myung Dae-Seong, Seo Ji-Hyun, Jo Hyun Jin, Kim Seon Mie, Lim Seon Hee, Kim Hyun Jin, Baik Gwang Ho, Choi Sang Hyeon, Choi Suck Chei
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
J Neurogastroenterol Motil. 2018 Oct 1;24(4):603-613. doi: 10.5056/jnm18068.
BACKGROUND/AIMS: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea.
A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with the Rome III criteria, and serology (IgG).
A total of 1714 subjects without organic disease were enrolled. The mean (± SD) age was 51.5 (± 12.7) years, and 917 patients (53.5%) were female. The proportion of seropositivity was 51.0% (874/1714). The prevalence of FD was 10.3% (176/1714), and the subtypes of postprandial distress syndrome alone, epigastric pain syndrome alone, and postprandial distress syndrome-epigastric pain syndrome overlap were 4.8%, 3.0%, and 2.5%, respectively. Multivariate analysis showed that female gender (OR, 1.58; 95% CI, 1.14-2.21) and education below college level (OR, 1.45; 95% CI, 1.01-2.07) were related to FD. Multivariate analysis based on age 60 showed female gender as a significant (OR, 2.90; 95% CI, 1.06-7.94) factor in the group ≥ 60 years.
The prevalence of FD was 10.3% in the health check-up population in Korea. Female sex and education below college level were risk factors for FD. Female sex is a risk factor for FD in old age, underscoring the need for close attention in this age group.
背景/目的：功能性消化不良（FD）是最常见的胃肠道疾病之一，在全球范围内造成社会和经济负担。本研究旨在确定韩国三级医疗中心健康体检人群中FD的患病率及危险因素。
2016年9月至2017年6月期间，在韩国9家三级医疗中心开展了一项全国多中心前瞻性研究。根据内镜检查结果、采用罗马Ⅲ标准的问卷以及血清学检查（IgG）对总共2525名受试者进行了调查。
共纳入1714名无器质性疾病的受试者。平均（±标准差）年龄为51.5（±12.7）岁，917例患者（53.5%）为女性。血清学阳性率为51.0%（874/1714）。FD的患病率为10.3%（176/1714），单纯餐后不适综合征、单纯上腹痛综合征以及餐后不适综合征-上腹痛综合征重叠亚型的患病率分别为4.8%、3.0%和2.5%。多因素分析显示，女性（比值比[OR]，1.58；95%置信区间[CI]，1.14-2.21）和大专以下学历（OR，1.45；95%CI，1.01-2.07）与FD相关。基于60岁进行的多因素分析显示，在≥60岁的人群中，女性是FD的一个显著（OR，2.90；95%CI，1.06-7.94）危险因素。
韩国健康体检人群中FD的患病率为10.3%。女性和大专以下学历是FD的危险因素。女性是老年FD的危险因素，这凸显了对该年龄组密切关注的必要性。
