Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China ; Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Curr Genomics. 2012 Nov;13(7):533-47. doi: 10.2174/138920212803251373.
Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging syndromes together with normal aging have suggested that accumulated damages might lead to exhaustion of resources that are required for physiological functions and thus accelerate aging. In this manuscript, combining the present understandings and latest findings, we focus mainly on discussing the role of chromatin remodeling in the repair of DNA double-strand breaks (DSBs) and regulation of aging.
细胞不断受到各种环境和内源性条件的影响，导致 DNA 损伤，这些损伤可被保守的 DNA 修复途径检测和修复，以维持基因组的完整性。染色质重塑在这个过程中至关重要，因为真核生物 DNA 组织成致密的染色质，这对所有与 DNA 相关的事件构成了天然的障碍。对人类早衰综合征和正常衰老的研究表明，积累的损伤可能导致生理功能所需资源的耗尽，从而加速衰老。在本文中，结合目前的认识和最新的发现，我们主要讨论了染色质重塑在修复 DNA 双链断裂（DSBs）和调节衰老中的作用。
