自闭症的社会和非社会认知控制的功能神经影像学。
Functional neuroimaging of social and nonsocial cognitive control in autism.
机构信息
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA,
出版信息
J Autism Dev Disord. 2013 Dec;43(12):2903-13. doi: 10.1007/s10803-013-1837-4.
Abstract
This study investigated cognitive control of social and nonsocial information in autism using functional magnetic resonance imaging. Individuals with autism spectrum disorders (ASDs) and a neurotypical control group completed an oddball target detection task where target stimuli were either faces or nonsocial objects previously shown to be related to circumscribed interests in autism. The ASD group demonstrated relatively increased activation to social targets in right insular cortex and in left superior frontal gyrus and relatively decreased activation to nonsocial targets related to circumscribed interests in multiple frontostriatal brain regions. Findings suggest that frontostriatal recruitment during cognitive control in ASD is contingent on stimulus type, with increased activation for social stimuli and decreased activation for nonsocial stimuli related to circumscribed interests.
摘要
本研究使用功能磁共振成像技术探究了自闭症患者对社会信息和非社会信息的认知控制。自闭症谱系障碍（ASD）患者和神经典型对照组完成了一项奇特目标检测任务，其中目标刺激物是之前与自闭症患者的特定兴趣相关的面孔或非社会物体。ASD 组在右侧脑岛和左侧额上回中表现出相对增加的对社会目标的激活，而在多个额-纹状体脑区中对与特定兴趣相关的非社会目标的激活则相对减少。研究结果表明，在 ASD 患者的认知控制过程中，额纹状体的募集取决于刺激类型，社会刺激会引起更多的激活，而与特定兴趣相关的非社会刺激则会引起较少的激活。
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