1Department of Dermatology, Kecioren Training and Research Hospital, Ankara, Turkey.
Angiology. 2014 Jan;65(1):74-8. doi: 10.1177/0003319713485805. Epub 2013 May 1.
Psoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.
银屑病与动脉粥样硬化风险增加相关。内皮功能障碍是动脉粥样硬化形成过程中的关键早期步骤，通常通过测量动脉僵硬度来研究。我们旨在研究银屑病患者动脉僵硬与高敏 C 反应蛋白（hsCRP）之间的关系。共有 32 名银屑病患者和 35 名其他皮肤病患者纳入研究。比较了 hsCRP 水平和动脉僵硬测量值。两组之间的动脉僵硬差异有统计学意义（P =.01）。动脉僵硬与疾病持续时间或疾病活动度无关（P =.34 和.64）。在银屑病患者中，动脉僵硬与年龄、性别、体重指数、舒张压和 hsCRP 水平呈正相关（P <.05）。这些发现为炎症、动脉粥样硬化提前发生与银屑病之间的联系提供了进一步证据。
