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1
Decarboxylation of uroporphyrinogen III by erythrocyte uroporphyrinogen decarboxylase. Evidence for a random decarboxylation mechanism.红细胞尿卟啉原脱羧酶对尿卟啉原III的脱羧作用。随机脱羧机制的证据。
Biochem J. 1990 Jun 1;268(2):513-5. doi: 10.1042/bj2680513.
2
Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase.大鼠肝脏尿卟啉原脱羧酶对卟啉原的脱羧作用。
Biochem J. 1979 Nov 1;183(2):455-8. doi: 10.1042/bj1830455.
3
Random decarboxylation of uroporphyrinogen III by human hepatic uroporphyrinogen decarboxylase.人肝脏尿卟啉原脱羧酶对尿卟啉原III的随机脱羧作用。
J Chromatogr. 1991 May 31;566(2):409-13. doi: 10.1016/0378-4347(91)80257-d.
4
Liver porphyrinogen carboxylase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I.六氯苯致卟啉症大鼠的肝脏卟啉原羧化酶。对Ⅲ系列中间卟啉原和尿卟啉原Ⅰ的研究。
Int J Biochem. 1987;19(4):365-72. doi: 10.1016/0020-711x(87)90010-3.
5
Some kinetic properties of human red cell uroporphyrinogen decarboxylase.人红细胞尿卟啉原脱羧酶的一些动力学特性。
Biochim Biophys Acta. 1980 Jan 11;611(1):174-86. doi: 10.1016/0005-2744(80)90053-4.
6
Decarboxylation of uroporphyrinogen I and III in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced porphyria in mice.2,3,7,8-四氯二苯并对二恶英诱导的小鼠卟啉症中尿卟啉原I和III的脱羧作用
Int J Biochem. 1984;16(5):561-5. doi: 10.1016/0020-711x(84)90175-7.
7
Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins.大鼠肝脏尿卟啉原脱羧酶的研究。卟啉原I和III作为底物的比较以及卟啉的抑制作用。
Biochem J. 1981 Apr 1;195(1):241-50. doi: 10.1042/bj1950241.
8
Tetrapyrroles as substrates and inhibitors of porphyrinogen carboxy - lyase from rat liver.四吡咯作为大鼠肝脏中卟啉原羧化酶的底物和抑制剂
Acta Physiol Lat Am. 1976;26(5):403-14.
9
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III.人红细胞尿卟啉原脱羧酶的纯化及性质。一种催化尿卟啉原I和III四个连续脱羧反应的单一酶。
J Biol Chem. 1983 Feb 25;258(4):2454-60.
10
Order of uroporphyrinogen III decarboxylation on incubation of porphobilinogen and uroporphyrinogen III with erythrocyte uroporphyrinogen decarboxylase.在将胆色素原和尿卟啉原III与红细胞尿卟啉原脱羧酶一起孵育时尿卟啉原III脱羧的顺序
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):529-32. doi: 10.1042/bj2890529.

引用本文的文献

1
Order of uroporphyrinogen III decarboxylation on incubation of porphobilinogen and uroporphyrinogen III with erythrocyte uroporphyrinogen decarboxylase.在将胆色素原和尿卟啉原III与红细胞尿卟啉原脱羧酶一起孵育时尿卟啉原III脱羧的顺序
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):529-32. doi: 10.1042/bj2890529.
2
Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides.球形红杆菌尿卟啉原脱羧酶的纯化及性质
Biochem J. 1993 Aug 1;293 ( Pt 3)(Pt 3):703-12. doi: 10.1042/bj2930703.
3
Action of uroporphyrinogen decarboxylase on uroporphyrinogen-III: a reassessment of the clockwise decarboxylation hypothesis.尿卟啉原脱羧酶对尿卟啉原III的作用：对顺时针脱羧假说的重新评估。
Biochem J. 1991 Sep 15;278 ( Pt 3)(Pt 3):901-3. doi: 10.1042/bj2780901.
4
Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles.通过hem12突变等位基因的序列分析鉴定影响酵母尿卟啉原脱羧酶活性的氨基酸变化。
Biochem J. 1992 Dec 15;288 ( Pt 3)(Pt 3):753-7. doi: 10.1042/bj2880753.

本文引用的文献

1
Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase.红细胞中的卟啉生物合成。III. 尿卟啉原及其脱羧酶。
J Biol Chem. 1958 Jun;232(2):1141-62.
2
Separation of porphyrin isomers by high-performance liquid chromatography.通过高效液相色谱法分离卟啉异构体。
Biochem J. 1983 May 1;211(2):435-8. doi: 10.1042/bj2110435.
3
High-performance liquid chromatography of naturally occurring 8-, 7-, 6-, 5- and 4-carboxylic porphyrin isomers.天然存在的8-、7-、6-、5-和4-羧基卟啉异构体的高效液相色谱分析
J Chromatogr. 1983 Dec 30;282:629-41. doi: 10.1016/s0021-9673(00)91640-6.
4
Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase.牛肝尿卟啉原脱羧酶的纯化与特性分析
Biochemistry. 1983 Sep 27;22(20):4664-72. doi: 10.1021/bi00289a009.
5
Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers.尿卟啉原脱羧酶。多氯联苯异构体对其的纯化、性质及抑制作用
J Biol Chem. 1983 Apr 10;258(7):4285-92.
6
Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties.卟啉生物合成。VII. 来自禽红细胞的卟啉原羧基裂解酶。纯化及性质
Biochim Biophys Acta. 1970 Feb 11;198(2):353-63. doi: 10.1016/0005-2744(70)90068-9.
7
High-performance liquid chromatography of type-III heptocarboxylic porphyrinogen isomers.III型庚羧酸卟啉原异构体的高效液相色谱分析
Biochem J. 1987 Oct 1;247(1):229-32. doi: 10.1042/bj2470229.
8
An inherited enzymatic defect in porphyria cutanea tarda: decreased uroporphyrinogen decarboxylase activity.迟发性皮肤卟啉症中的一种遗传性酶缺陷：尿卟啉原脱羧酶活性降低。
J Clin Invest. 1976 Nov;58(5):1089-97. doi: 10.1172/JCI108560.
9
Macrocyclic intermediates in the biosynthesis of porphyrins.卟啉生物合成中的大环中间体。
Philos Trans R Soc Lond B Biol Sci. 1976 Feb 5;273(924):191-206. doi: 10.1098/rstb.1976.0009.

红细胞尿卟啉原脱羧酶对尿卟啉原III的脱羧作用。随机脱羧机制的证据。

Decarboxylation of uroporphyrinogen III by erythrocyte uroporphyrinogen decarboxylase. Evidence for a random decarboxylation mechanism.

作者信息

Luo J, Lim C K

机构信息

Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.

出版信息

Biochem J. 1990 Jun 1;268(2):513-5. doi: 10.1042/bj2680513.

DOI:10.1042/bj2680513
PMID:2363688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1131463/
Abstract

The isomeric composition of type-III heptacarboxylic porphyrinogens derived from decarbosylation of uroporphyrinogen III by erythrocyte uroporphyringogen decarboxylase was analysed by h.p.l.c. with electrochemical detection. All four possible isomers were identified, and there were little differences in the proportion of isomers formed by erythrocytes from normal subjects and from patients with sporadic porphyria cutanea tarda. The results provide conclusive evidence that the normal decarboxylation pathway is random in nature, and the fourth isomer only increases when enzyme abnormality is found.

摘要

采用高效液相色谱-电化学检测法分析了由红细胞尿卟啉原脱羧酶使尿卟啉原III脱羧生成的III型七羧基卟啉原的异构体组成。鉴定出了所有四种可能的异构体，正常受试者和散发性迟发性皮肤卟啉症患者红细胞形成的异构体比例几乎没有差异。结果提供了确凿证据，表明正常脱羧途径本质上是随机的，只有在发现酶异常时第四种异构体才会增加。