线粒体 DNA 完整性的维持——关键分析与更新。
The maintenance of mitochondrial DNA integrity--critical analysis and update.
机构信息
Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, AL 36688, USA.
出版信息
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a012641. doi: 10.1101/cshperspect.a012641.
Abstract
DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are constantly damaged by noxious agents. Eukaryotic cells have developed efficient mechanisms to deal with this assault. The process of DNA repair in mitochondria, initially believed nonexistent, has now evolved into a mature area of research. In recent years, it has become increasingly appreciated that mitochondria possess many of the same DNA repair pathways that the nucleus does. Moreover, a unique pathway that is enabled by high redundancy of the mitochondrial DNA and allows for the disposal of damaged DNA molecules operates in this organelle. In this review, we attempt to present a unified view of our current understanding of the process of DNA repair in mitochondria with an emphasis on issues that appear controversial.
摘要
线粒体中的 DNA 分子，就像真核细胞细胞核中的那些分子一样，不断受到有害物质的损伤。真核细胞已经开发出有效的机制来应对这种攻击。最初被认为不存在的线粒体 DNA 修复过程，现在已经发展成为一个成熟的研究领域。近年来，人们越来越认识到，线粒体拥有与细胞核相同的许多 DNA 修复途径。此外，线粒体中还存在一种独特的途径，这种途径得益于线粒体 DNA 的高度冗余，能够处理受损的 DNA 分子。在这篇综述中，我们试图提出一个统一的观点，介绍我们目前对线粒体 DNA 修复过程的理解，并强调一些似乎存在争议的问题。
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