硬皮病患者培养的外周血单核细胞中白细胞介素-1和肿瘤坏死因子α的产生增强。
Enhanced production of interleukin-1 and tumor necrosis factor alpha by cultured peripheral blood monocytes from patients with scleroderma.
作者信息
Umehara H, Kumagai S, Murakami M, Suginoshita T, Tanaka K, Hashida S, Ishikawa E, Imura H
机构信息
Second Department of Internal Medicine, Kyoto University Medical School, Japan.
出版信息
Arthritis Rheum. 1990 Jun;33(6):893-7. doi: 10.1002/art.1780330619.
Cultured peripheral blood mononuclear cells from 20 patients with scleroderma were shown to produce high levels of interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor alpha. There were positive correlations between the production of these 3 molecules. Purified monocytes from these patients produced much more tumor necrosis factor alpha than did those from normal subjects, even without lipopolysaccharide stimulation. These results show the hyperactivity of monocytes from scleroderma patients.
研究表明，20例硬皮病患者的培养外周血单核细胞可产生高水平的白细胞介素-1α、白细胞介素-1β和肿瘤坏死因子α。这3种分子的产生之间存在正相关。这些患者的纯化单核细胞即使在没有脂多糖刺激的情况下，产生的肿瘤坏死因子α也比正常受试者的单核细胞多得多。这些结果表明硬皮病患者的单核细胞活性过高。
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