Naresh Kumar C V M, Sai Gopal D V R
Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati, 517502 India.
Indian J Virol. 2010 Jun;21(1):8-17. doi: 10.1007/s13337-010-0012-1. Epub 2010 Sep 3.
Chikungunya virus (CHIKV), a reemerging arboviral disease of public health concern is characterized by a triad of fever, rash and arthralgia. It was responsible for a number of epidemics in Asia and Africa. The severity of the current epidemic can be judged by the fact that an estimated 1.38 million people in India and one-third of the La Reunion population (by April 2006) were affected by CHIKV. Aedes aegypti and Aedes albopictus are the major mosquitoes transmitting CHIKV in Asia. Various neurological complications and CHIKV associated deaths were encountered during the current outbreak (2005-2010). The aggressive nature of the recent CHIKV epidemic was attributed to the mutations in the viral genome in addition to their adaptation and spread to vectors like Aedes albopictus. Proper diet, adequate rest and symptomatic treatment using non-salicylate analgesics and Non-steroidal anti inflammatory drugs (NSAIDS) helped the patients in recovering from CHIKV infections. In the absence of an effective vaccine, rapid implementation of mosquito control measures and establishment of a system for continuous surveillance of the disease seems to be the only possible solution to prevent any such outbreak in the near future.
基孔肯雅病毒(CHIKV)是一种再度出现的、引起公共卫生关注的虫媒病毒疾病,其特征为发热、皮疹和关节痛三联征。它曾在亚洲和非洲引发多次疫情。从印度估计有138万人以及留尼汪三分之一的人口(截至2006年4月)受到基孔肯雅病毒感染这一事实,可判断当前疫情的严重程度。埃及伊蚊和白纹伊蚊是亚洲传播基孔肯雅病毒的主要蚊子。在当前疫情(2005 - 2010年)期间,出现了各种神经并发症以及与基孔肯雅病毒相关的死亡病例。近期基孔肯雅病毒疫情的侵袭性,除了病毒适应并传播至白纹伊蚊等病媒外,还归因于病毒基因组的突变。合理饮食、充足休息以及使用非水杨酸类镇痛药和非甾体抗炎药(NSAIDs)进行对症治疗,有助于患者从基孔肯雅病毒感染中康复。在缺乏有效疫苗的情况下,迅速实施蚊虫控制措施并建立疾病持续监测系统,似乎是在不久的将来预防此类疫情爆发的唯一可行办法。