Wu Nana, Ge Qinjuan, Feng Qingchuan, Zhang Jun, Liu Xiaoxia, Sun Caihong, Xu Yongkang, He Guangli, Zhang Chiyu
Institute of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013 Jiangsu China.
Indian J Virol. 2011 Dec;22(2):77-83. doi: 10.1007/s13337-011-0041-4. Epub 2011 Jun 30.
The constant increase in the number of drug users and rapidly spread of Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) among drug users result in a serious public health problem in China. To investigate HCV prevalence among drug users in Zhenjiang city, Jiangsu, China, 207 drug users from Zhenjiang were enrolled in this study during 2009 and the prevalence of HCV, HIV and syphilis infection were detected. HCV prevalence among injection drug users (IDUs) was 81.6%, significantly higher than that (22.9%) among oral drug users (P < 0.001), suggesting a strong association of HCV infection with injection drug use (IDU). Most drug users were more than 25 years old (89.2%), single (60.5%, including single and divorced/widowed), and had a history of drug abuse over 6 years (92.9%). HCV prevalence among drug users with middle (72.6%) or high (83.8%) school diplomas was significantly higher than that among those with lower (46.9%) education level (P = 0.007). HCV prevalence among IDUs did not obviously change along with the increase in duration of drug use and in frequency of injection per day, suggesting less association of HCV infection with both variables. These results suggest that most Chinese addicts might start drug use after their middle/high school education. To reduce drug use and to prevent HIV and HCV transmission via IDU, large-scale drug prevention educations should be urgently conducted in all China's middle and high schools.
吸毒人员数量的不断增加以及丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）在吸毒人员中的迅速传播，在中国引发了严重的公共卫生问题。为调查中国江苏省镇江市吸毒人员中HCV的流行情况，2009年期间，207名来自镇江的吸毒人员被纳入本研究，并检测了HCV、HIV和梅毒感染的流行情况。注射吸毒者（IDU）中HCV的流行率为81.6%，显著高于口服吸毒者（22.9%）（P<0.001），表明HCV感染与注射吸毒（IDU）密切相关。大多数吸毒人员年龄超过25岁（89.2%），单身（60.5%，包括单身和离异/丧偶），且有超过6年的药物滥用史（92.9%）。具有中学（72.6%）或高中（83.8%）文凭的吸毒人员中HCV的流行率显著高于教育水平较低（46.9%）的吸毒人员（P = 0.007）。IDU中HCV的流行率并未随着吸毒时间的增加和每天注射频率的增加而明显变化，表明HCV感染与这两个变量的关联较小。这些结果表明，大多数中国吸毒者可能在接受中学/高中教育后开始吸毒。为减少吸毒行为并预防通过IDU传播HIV和HCV，应在中国所有中学和高中紧急开展大规模的毒品预防教育。
