Weber Johanna, Scholz Konstantin J, Schenke Isabelle M, Pfab Florian, Cieplik Fabian, Hiller Karl-Anton, Buchalla Wolfgang, Sahm Camilla, Kirschneck Christian, Paddenberg-Schubert Eva
Department of Conservative Dentistry and Periodontology, University Hospital Regensburg, Regensburg, Germany.
Department of Orthodontics, University Hospital Regensburg, Regensburg, Germany.
Clin Oral Investig. 2024 Apr 25;28(5):272. doi: 10.1007/s00784-024-05669-4.
Chewing gums containing antiseptics or other antimicrobial substances may be effective in reducing plaque and gingivitis. Therefore, the aim of this randomized placebo-controlled clinical trial was to investigate the efficacy of a novel antimicrobial chewing gum containing essential oils (cinnamon, lemon, peppermint) and extracts on reduction of dental plaque and gingivitis as well as on oral health-related quality of life (OHRQoL) in adolescent orthodontic patients.
52 patients (11-22 years of age) were randomly assigned to use a test chewing gum (COVIDGUM, Clevergum) or a commercially available control chewing gum over a period of 10 days. Approximal plaque index (API), papillary bleeding index (PBI) and an OHRQoL questionnaire for children (COHIP-G19) were assessed at baseline (BL), after 10 days (10d) and 30 days (30d). In addition, oral health and oral hygiene related questions of the COHIP-G19 questionnaire were evaluated separately in subscales at each timepoint. Data were analyzed using non-parametrical statistical procedures (α = 0.05).
API and PBI decreased significantly over time from BL to 10d and from BL to 30d in both groups, without significant differences between the groups. In both groups, the COHIP-G19 score, oral health subscale and oral hygiene subscale decreased significantly over time. Regarding the oral hygiene subscale, the test group showed significantly better scores at 30d (p = 0.011).
Both chewing gums performed similarly effective in terms of reducing plaque accumulation and gingival inflammation and improving OHRQoL.
Chewing gums without antimicrobial ingredients may be sufficient to decrease plaque accumulation and gingival inflammation.
含有防腐剂或其他抗菌物质的口香糖可能在减少牙菌斑和牙龈炎方面有效。因此，这项随机安慰剂对照临床试验的目的是研究一种含有精油（肉桂、柠檬、薄荷）和提取物的新型抗菌口香糖对青少年正畸患者减少牙菌斑和牙龈炎以及口腔健康相关生活质量（OHRQoL）的疗效。
52名患者（11 - 22岁）被随机分配在10天内使用测试口香糖（COVIDGUM，Clevergum）或市售对照口香糖。在基线（BL）、10天（10d）和30天（30d）时评估邻面菌斑指数（API）、龈乳头出血指数（PBI）以及儿童口腔健康相关生活质量问卷（COHIP - G19）。此外，在每个时间点对COHIP - G19问卷中与口腔健康和口腔卫生相关的问题分别在子量表中进行评估。使用非参数统计方法（α = 0.05）分析数据。
两组的API和PBI从BL到10d以及从BL到30d均随时间显著下降，两组之间无显著差异。两组的COHIP - G19评分、口腔健康子量表和口腔卫生子量表均随时间显著下降。关于口腔卫生子量表，测试组在30d时得分显著更高（p = 0.011）。
两种口香糖在减少菌斑积聚、牙龈炎症和改善OHRQoL方面表现出相似的效果。
不含抗菌成分的口香糖可能足以减少菌斑积聚和牙龈炎症。
