State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, and University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
Org Lett. 2013 May 17;15(10):2414-7. doi: 10.1021/ol400875n. Epub 2013 May 2.
A new 6/6/5/6-fused limonoid, phyllanthoid A (1), possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis (Euphorbiaceae), together with a new related limonoid, phyllanthoid B (2). Their structures were determined by spectroscopic analysis and single-crystal X-ray diffraction in the case of 1. Compound 1 displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.
从大戟科叶下珠属植物叶下珠（Phyllanthus cochinchinensis）中分离得到一个新的 6/6/5/6-稠合的柠檬苦素，叶下珠素 A（1），其具有 19/30 和 19/29 氧桥。此外，还分离得到一个新的相关柠檬苦素，叶下珠素 B（2）。通过光谱分析和单晶 X 射线衍射确定了它们的结构。化合物 1 对多食性植食性昆虫斜纹夜蛾（Spodoptera exigua）表现出中等的拒食活性，并对 MCF-7 细胞系具有细胞毒性。
