State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
J Nat Prod. 2014 Mar 28;77(3):472-82. doi: 10.1021/np400678h. Epub 2013 Nov 20.
Eight new aphanamixoid-type aphanamixoids (C-J, 1-8) and six new prieurianin-type limonoids, aphanamixoids K-P (9-14), along with 10 known terpenoids were isolated from Aphanamixis polystachya, and their structures were established by spectroscopic data analysis. Among the new limonoids, 13 compounds exhibited antifeedant activity against the generalist Helicoverpa armigera, a plant-feeding insect, at various concentration levels. In particular, compounds 1, 4, and 5 showed potent activities with EC50 values of 0.017, 0.008, and 0.012 μmol/cm(2), respectively. On the basis of a preliminary structure-activity relationship analysis, some potential active sites in the aphanamixoid-type limonoid molecules are proposed.
从八角莲中分离得到了 8 种新的阿朴菲型阿朴菲类化合物（C-J，1-8）和 6 种新的 prieurianin 型柠檬苦素，阿朴菲类化合物 K-P（9-14），以及 10 种已知的萜类化合物。通过光谱数据分析确定了它们的结构。在新的柠檬苦素中，有 13 种化合物在不同浓度水平下对植食性昆虫烟青虫表现出抗食活性。特别是化合物 1、4 和 5 表现出很强的活性，EC50 值分别为 0.017、0.008 和 0.012 μmol/cm(2)。基于初步的构效关系分析，提出了阿朴菲型柠檬苦素分子中的一些潜在活性部位。
