Muséum National d'Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes (UMR 7245 CNRS-MNHN), 57 rue Cuvier (CP 54), 75005 Paris, France.
Nat Prod Rep. 2013 Jun;30(6):765-82. doi: 10.1039/c3np70016j.
Covering: up to early 2013. Fungal polyketides and their hybrid non ribosomal peptide derivatives are characterized by often striking structural features and biological activities. Their diversity and their complexity arise from highly organized and programmable biosynthetic pathways and have been challenged by many synthetic chemists. This review will conceptually illustrate how complexity can be generated, starting from a general biosynthetic purpose (the fundaments of PKS-NRPS assembly lines) and finally showing how the particular class of hirsutellone compounds has emerged from such processes in relation to post-elongation and secondary tailoring events. Synthetic efforts to produce these natural products will be described with a special emphasis on complexity-generating strategies and steps. Thus, the biosynthetic and synthetic works will be analyzed in a continuous flow, focusing on both the logic of Nature and organic chemists.
截至 2013 年初。真菌聚酮化合物及其杂种非核糖体肽衍生物的特点是通常具有显著的结构特征和生物活性。它们的多样性和复杂性源于高度组织化和可编程的生物合成途径，这给许多合成化学家带来了挑战。本综述将从一般的生物合成目的（聚酮合酶-非核糖体肽装配线的基础）出发，从概念上说明如何产生复杂性，最后展示与延伸后和二级修饰事件相关的，类毛壳素化合物是如何从这些过程中出现的。将描述产生这些天然产物的合成努力，特别强调产生复杂性的策略和步骤。因此，生物合成和合成工作将在连续的流程中进行分析，重点关注自然和有机化学家的逻辑。
