毛壳菌素F，一种来自木霉属真菌BCC 7579种子的抗结核生物碱二聚体。
Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579.
作者信息
Isaka Masahiko, Prathumpai Wai, Wongsa Patcharaporn, Tanticharoen Morakot
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani.
出版信息
Org Lett. 2006 Jun 22;8(13):2815-7. doi: 10.1021/ol060926x.
[structure: see text] Hirsutellone F (7), a novel alkaloid dimer, was isolated together with known monomers, hirsutellones A (1), B (2), and C (3), from the seed fungus Trichoderma sp. BCC 7579. The structure of 7 was elucidated by spectroscopic analysis. Studies on biomimetic chemistry, using the dimer 7, suggested that compound 8 (17,1'-dehydrohirsutellone B) should be the precursor for all hirsutellones.
[结构：见正文] 从种子真菌木霉属Trichoderma sp. BCC 7579中分离得到了一种新型生物碱二聚体——多毛壳菌素F（7），以及已知的单体多毛壳菌素A（1）、B（2）和C（3）。通过光谱分析阐明了7的结构。使用二聚体7进行的仿生化学研究表明，化合物8（17,1'-脱氢多毛壳菌素B）应该是所有多毛壳菌素的前体。
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