Department of Pharmacy Practice, College of Pharmacy, Touro University California, Vallejo, CA 94592, USA.
Am J Health Syst Pharm. 2013 May 15;70(10):877-86. doi: 10.2146/ajhp120238.
The impact of pharmacist interventions on short-term clinical markers and long-term cardiovascular risk in patients with type 2 diabetes is investigated.
Selected health outcomes were retrospectively analyzed in 147 adults with type 2 diabetes whose care was managed by a team of providers including a pharmacist (the enhanced care group) and a matched sample of patients (n = 147) managed by a primary care physician only (the control group). All patients received services through the same health maintenance organization (HMO). The primary study endpoints were (1) the changes from baseline to 12-month follow-up in glycosylated hemoglobin (HbA(1c)), low-density lipoprotein cholesterol (LDL-C), and blood pressure (BP) values, (2) rates of attainment of HbA(1c), LDL-C and BP goals, and (3) changes from baseline in predicted 10-year risks of coronary heart disease (CHD) and stroke.
During the 12-month study period, the mean HbA(1c) value was decreased from 9.5% to 6.9% in the enhanced care group and from 9.3% to 8.4% in the control group (p < 0.001); patients in the enhanced care group were significantly more likely to attain goals for HbA(1c) (odds ratio [OR], 3.9), LDL-C (OR, 2.0), and BP reduction (OR, 2.0) and three times more likely to attain all three goals (OR, 3.2). The estimated 10-year risk of CHD was decreased from 16.4% to 9.3% with enhanced care versus a reduction from 17.4% to 14.8% with usual care (p < 0.001).
The addition of a pharmacist to an HMO primary care team improved short-term surrogate markers as well as long-term cardiovascular risk in adult patients with type 2 diabetes.
研究药师干预对 2 型糖尿病患者短期临床指标和长期心血管风险的影响。
回顾性分析了由包括药师在内的医疗团队(强化护理组)管理的 147 名 2 型糖尿病成人患者(n=147)和仅由初级保健医生管理的匹配样本患者(对照组)(n=147)的健康结果。所有患者均通过同一健康维护组织(HMO)接受服务。主要研究终点为:(1)从基线到 12 个月随访时糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)和血压(BP)值的变化;(2)达到 HbA1c、LDL-C 和 BP 目标的比例;(3)从基线到预测的 10 年内冠心病(CHD)和中风风险的变化。
在 12 个月的研究期间,强化护理组的平均 HbA1c 值从 9.5%降至 6.9%,对照组从 9.3%降至 8.4%(p<0.001);强化护理组患者更有可能达到 HbA1c(比值比[OR],3.9)、LDL-C(OR,2.0)和 BP 降低(OR,2.0)的目标,达到所有三个目标的可能性增加了三倍(OR,3.2)。强化护理组患者的 10 年 CHD 风险从 16.4%降至 9.3%,而常规护理组从 17.4%降至 14.8%(p<0.001)。
在 HMO 初级保健团队中加入药师可改善 2 型糖尿病成年患者的短期替代指标和长期心血管风险。