Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1468-72. doi: 10.1161/ATVBAHA.112.300157. Epub 2013 May 2.
Genetic and epigenetic factors are of great importance in cardiovascular biology and disease. Tobacco-smoking, one of the most important cardiovascular risk factors, is itself partially determined by genetic background and is associated with altered epigenetic patterns. This could render the genetics and epigenetics of smoking-related cardiovascular disease a textbook example of environmental epigenetics and modern approaches to multimodal data analysis. A pronounced association of smoking-related methylation patterns in the F2RL3 gene with prognosis in patients with stable coronary heart disease has recently been described. Nonetheless, surprisingly little concrete knowledge on the role of specific genetic variants and epigenetic modifications in the development of cardiovascular diseases in people who smoke has been accumulated. Beyond the current knowledge, the present review briefly outlines some chief challenges and priorities for moving forward in this field.
遗传和表观遗传因素在心血管生物学和疾病中具有重要意义。吸烟是最重要的心血管危险因素之一，其本身部分取决于遗传背景，并与表观遗传模式的改变有关。这使得与吸烟有关的心血管疾病的遗传学和表观遗传学成为环境表观遗传学和现代多模态数据分析方法的典型范例。最近有研究描述了 F2RL3 基因中与吸烟相关的甲基化模式与稳定型冠心病患者预后之间的显著相关性。尽管如此，关于吸烟人群中特定遗传变异和表观遗传修饰在心血管疾病发展中的作用，人们的具体认识仍然非常有限。除了目前的知识外，本文简要概述了在该领域取得进展所面临的一些主要挑战和优先事项。
