Erban Radek, Flegg Mark B, Papoian Garegin A
Mathematical Institute, University of Oxford, 24-29 St. Giles', Oxford, OX1 3LB, UK,
Bull Math Biol. 2014 Apr;76(4):799-818. doi: 10.1007/s11538-013-9844-3. Epub 2013 May 3.
Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously developed in the literature. The second hybrid model is based on the application of a recently developed two-regime method (TRM) to a fully molecular-based model, which is also developed in this paper. The results of hybrid models are compared with the results of the molecular-based model. It is shown that both approaches give comparable results, although the TRM model better agrees quantitatively with the molecular-based model.
研究了丝状伪足中肌动蛋白动力学的两种多尺度（混合）随机反应扩散模型。两种混合算法都结合了基于区室和基于分子的随机反应扩散模型。第一个混合模型基于文献中先前开发的模型。第二个混合模型基于将最近开发的双机制方法（TRM）应用于本文中也开发的完全基于分子的模型。将混合模型的结果与基于分子的模型的结果进行了比较。结果表明，尽管TRM模型在定量上与基于分子的模型更吻合，但两种方法都给出了可比的结果。
