在囊性纤维化患者的呼吸道感染中，铜绿假单胞菌种群会广泛多样化。
Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis.
机构信息
Regional Adult Cystic Fibrosis Unit, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, United Kingdom.
出版信息
J Cyst Fibros. 2013 Dec;12(6):790-3. doi: 10.1016/j.jcf.2013.04.003. Epub 2013 May 1.
BACKGROUND
Populations of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa undergo extensive diversification in the cystic fibrosis (CF) lung during long-term chronic infections.
METHODS
We analyzed sets of 40 isolates from the sputa of five CF patients, each chronically infected with a different non-LES strain of P. aeruginosa. For each sample (two per patient), diversity was assessed by characterizing nine phenotypic traits.
RESULTS
All P. aeruginosa populations were highly diverse, with the majority of phenotypic variation being due to within-sample diversity.
CONCLUSIONS
Maintenance of diverse populations in the CF lung is a common feature of P. aeruginosa infections.
背景
在长期慢性感染期间，囊性纤维化 (CF) 肺中的 Liverpool 流行株 (LES) 铜绿假单胞菌经历了广泛的多样化。
方法
我们分析了五名 CF 患者的痰液中 40 个分离株的集合，每个患者都长期感染了不同的非 LES 铜绿假单胞菌菌株。对于每个样本（每个患者两个样本），通过表征九个表型特征来评估多样性。
结果
所有铜绿假单胞菌种群都具有高度多样性，大多数表型变异归因于样本内多样性。
结论
CF 肺中多样化种群的维持是铜绿假单胞菌感染的一个共同特征。
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