Moret Inés, Cerrillo Elena, Navarro-Puche Ana, Iborra Marisa, Rausell Francisco, Tortosa Luis, Beltrán Belén
Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; CIBEREHD, España.
Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; Servicio de Medicina Digestiva, Hospital Universitari i Politècnic La Fe, Valencia, España.
Gastroenterol Hepatol. 2014 Jan;37(1):28-34. doi: 10.1016/j.gastrohep.2013.01.008. Epub 2013 May 1.
Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood.
克罗恩病（CD）的特征是透壁性炎症，最常发生于回肠末端区域。尽管该疾病的生理病理机制尚未完全明确，但免疫反应失调与活性氧（ROS）的大量产生有关。这些因素与称为抗氧化防御的复杂系统相关，其功能是调节ROS，从而防止这些因素产生有害影响。然而，ROS产生与抗氧化剂清除ROS之间的失衡现象已被广泛描述，并导致氧化应激。在本文中，我们描述了肠道黏膜和外周血中氧化应激的最重要研究结果。
