Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
J Am Acad Dermatol. 2013 Aug;69(2):238-44. doi: 10.1016/j.jaad.2013.03.014. Epub 2013 May 2.
Because vitamin D has immunomodulatory properties and immunologic mechanisms play a role in the pathogenesis of atopic dermatitis (AD), it is possible that vitamin D may influence the activity of AD.
The aim of the study was to correlate vitamin D concentrations in patients who had AD with clinical, immunologic, constitutional, and environmental factors, and to determine if vitamin D supplementation affects the clinical manifestations of AD.
Clinical and laboratory parameters of 95 patients with AD and 58 control subjects were measured. Severity of AD was assessed with the SCORAD index.
The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects. The frequency of bacterial skin infections was higher in patients with AD who had lower 25(OH)D₃ levels. No statistical associations between vitamin D levels and other multiple laboratory and clinical parameters were found. After supplementation both mean objective SCORAD and SCORAD index were significantly lower (P < .05).
All study patients were Caucasians and only one supplemental vitamin D dose and treatment duration were assessed.
The results from this study indicate that vitamin D supplementation may help ameliorate clinical signs of the disease and can be considered as a safe and well-tolerated form of therapy.
由于维生素 D 具有免疫调节特性，且免疫机制在特应性皮炎 (AD) 的发病机制中发挥作用，因此维生素 D 可能会影响 AD 的活动。
本研究旨在将 AD 患者的维生素 D 浓度与临床、免疫、体质和环境因素相关联，并确定维生素 D 补充是否会影响 AD 的临床表现。
测量了 95 例 AD 患者和 58 例对照者的临床和实验室参数。采用 SCORAD 指数评估 AD 的严重程度。
AD 患者的血清 25(OH)D3 平均浓度与对照组无统计学差异。25(OH)D₃水平较低的 AD 患者发生细菌皮肤感染的频率更高。未发现维生素 D 水平与其他多个实验室和临床参数之间存在统计学关联。补充后，平均客观 SCORAD 和 SCORAD 指数均显著降低（P<.05）。
所有研究患者均为白种人，仅评估了一次维生素 D 补充剂量和治疗持续时间。
本研究结果表明，维生素 D 补充可能有助于改善疾病的临床体征，可被视为一种安全且耐受良好的治疗形式。
