评估特应性皮炎患儿血清 25-羟维生素 D 水平：与 SCORAD 指数的相关性。

Assessment of serum 25-hydroxyvitamin d levels in children with atopic dermatitis: correlation with SCORAD index.

机构信息

From the Departments of *Dermatology, Venereology and Andrology, and †Clinical Pathology, Faculty of Medicine, South Valley University, Qina, Egypt; and ‡Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

出版信息

Dermatitis. 2013 Nov-Dec;24(6):296-301. doi: 10.1097/DER.0000000000000010.

DOI:10.1097/DER.0000000000000010

PMID:24201460

Abstract

BACKGROUND

Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an immunologic basis. It may have negative medical and social impacts on a patient and his family.

OBJECTIVES

To assess serum level of vitamin D among children with AD and determine its association with AD severity using the AD Scoring System Index.

STUDY DESIGN

A case-control study.

PATIENTS AND METHODS

Twenty-nine patients with AD in the age group between 2 and 12 years were enrolled in the study. The severity of the disease was determined by the AD scoring system. Thirty controls were recruited. Serum levels of 25-hydroxyvitamin D3 [25(OH)D3] were tested using commercial automated chemiluminescent microparticle immunoassay.

RESULTS

The mean value of vitamin D in children with AD was much lower than normal value, and there was a significant difference in the mean values of vitamin D between children with AD (5.4±1.9 ng/mL) and the controls (28.9±2.4 ng/mL). Serum 25(OH)D levels were found to be significantly higher in mild AD (14.6±3.5 ng/mL) compared with moderate (5.5±3.1 ng/mL) or severe AD (0.3±0.1 ng/mL); P<0.001.

CONCLUSION

Patients with AD have lower serum vitamin D levels than normal. Vitamin D deficiency might be related to the severity of AD.

摘要

背景

特应性皮炎（AD）是一种具有免疫基础的慢性炎症性皮肤疾病。它可能对患者及其家庭的身心健康产生负面影响。

目的

评估 AD 患儿血清维生素 D 水平，并使用 AD 评分系统指数确定其与 AD 严重程度的关系。

研究设计

病例对照研究。

患者和方法

研究纳入 29 名年龄在 2 至 12 岁之间的 AD 患儿。采用 AD 评分系统评估疾病严重程度。招募了 30 名对照者。使用商业自动化化学发光微粒子免疫分析法检测血清 25-羟维生素 D3 [25(OH)D3]水平。

结果

AD 患儿的维生素 D 平均值明显低于正常值，AD 患儿（5.4±1.9ng/mL）和对照组（28.9±2.4ng/mL）之间的维生素 D 平均值存在显著差异。与中重度 AD（5.5±3.1ng/mL 或 0.3±0.1ng/mL）相比，轻度 AD 患儿（14.6±3.5ng/mL）血清 25(OH)D 水平显著升高；P<0.001。