Department of Oral Surgery, Oral Medicine, Oral and Maxillofacial Radiology, School of Dental Medicine, University of Geneva, Geneva, Switzerland.
Implant Dent. 2013 Jun;22(3):295-303. doi: 10.1097/ID.0b013e3182906eb3.
The aims were to investigate whether the use of platelet-rich fibrin membranes (PRF) for socket filling could improve microarchitecture and intrinsic bone tissue quality of the alveolar bone after premolar extraction and to assess the influence of the surgical procedure before implant placement.
Twenty-three patients requiring premolar extraction followed by implant placement were randomized to three groups: (1) simple extraction and socket filling with PRF, (2) extraction with mucosal flap and socket filling with PRF, and (3) controls with simple extraction without socket filling. Implant placement was performed at week 8, and a bone biopsy was obtained for histomorphometric analysis.
Analysis by microcomputed tomography showed better bone healing with improvement of the microarchitecture (P < 0.05) in group 1. This treatment had also a significant effect (P < 0.05) on intrinsic bone tissue quality and preservation of the alveolar width. An invasive surgical procedure with a mucosal flap appeared to completely neutralize the advantages of the PRF.
These results support the use of a minimally traumatic procedure for tooth extraction and socket filling with PRF to achieve preservation of hard tissue.
本研究旨在探讨富血小板纤维蛋白（PRF）在磨牙拔除后用于牙槽窝填充是否可以改善牙槽骨的微观结构和固有骨组织质量，并评估种植体植入前手术程序的影响。
将 23 名需要拔除前磨牙并随后植入种植体的患者随机分为三组：（1）简单拔牙和 PRF 牙槽窝填充，（2）带黏膜瓣的拔牙和 PRF 牙槽窝填充，（3）简单拔牙不填充牙槽窝的对照组。第 8 周进行种植体植入，获取骨活检进行组织形态计量学分析。
通过微计算机断层扫描分析，发现第 1 组骨愈合情况更好，微观结构得到改善（P<0.05）。该治疗方法对固有骨组织质量和牙槽宽度的保持也有显著影响（P<0.05）。带有黏膜瓣的侵入性手术似乎完全抵消了 PRF 的优势。
这些结果支持采用微创拔牙和 PRF 牙槽窝填充程序来实现硬组织的保存。
