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一锅法通过非稳定亚甲胺叶立德的脱羧[3 + 2]环加成和无铜点击反应合成三唑并苯并二氮杂䓬

One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions.

机构信息

School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China.

Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA.

出版信息

Molecules. 2019 Feb 8;24(3):601. doi: 10.3390/molecules24030601.

DOI:10.3390/molecules24030601
PMID:30743991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6384988/
Abstract

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, -propargylation, and intramolecular click reactions.

摘要

介绍了一种含三唑并苯并二氮杂䓬的多环化合物的一锅合成方法。该反应过程涉及非稳定亚胺叶立德的脱羧基三组分[3+2]环加成、-炔丙基化和分子内环点击反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/6384988/e529fc5561ce/molecules-24-00601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/6384988/8e20f1a64141/molecules-24-00601-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/6384988/e529fc5561ce/molecules-24-00601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/6384988/8e20f1a64141/molecules-24-00601-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/6384988/e529fc5561ce/molecules-24-00601-g002.jpg

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