柚皮提取物对大鼠模型的心脏保护和肝脏保护作用
Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model.
作者信息
Putri Herwandhani, Nagadi Standie, Larasati Yonika Arum, Wulandari Nindi, Hermawan Adam, Nugroho Agung Endo
机构信息
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara II, Yogyakarta, Indonesia, 55281.
出版信息
Asian Pac J Trop Biomed. 2013 May;3(5):371-5. doi: 10.1016/S2221-1691(13)60079-9.
Abstract
OBJECTIVE
To observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.
METHODS
Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1 000 mg/kg body weight; Group IV: ChEE 1 000 mg/kg body weight; Group V: untreated (control).
RESULTS
ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.
CONCLUSION
ChEE has potency to be developed as cardioprotector agent in chemotherapy.
摘要
目的
观察阿霉素与酸橙果皮乙醇提取物（ChEE）联合应用对雌性斯普拉格-道利大鼠血清丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）活性以及心脏-肝脏组织病理学的影响。
方法
将阿霉素和ChEE（每组5只大鼠）分别给予五组，每组3只大鼠，持续11天。第一组：阿霉素（dox）4.67毫克/千克体重；第二组：阿霉素+ChEE 500毫克/千克体重；第三组：阿霉素+ChEE 1000毫克/千克体重；第四组：ChEE 1000毫克/千克体重；第五组：未处理（对照）。
结果
ChEE修复了阿霉素诱导的心脏毒性和肝毒性大鼠的心脏组织病理学特征，但未修复肝脏组织病理学特征，也未降低血清ALT和AST活性。
结论
ChEE有潜力开发成为化疗中的心脏保护剂。
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