Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
J Biomater Sci Polym Ed. 2013;24(8):972-85. doi: 10.1080/09205063.2012.728193. Epub 2012 Sep 25.
Novel biocompatible poly(lactide-co-glycolide) (PLGA) nanofiber mats with favorable biocompatibility and good mechanical strength were prepared, which could serve as an innovative type of tissue engineering scaffold or an ideal controllable drug delivery system. Both hydrophobic and hydrophilic drugs, Cefradine and 5-fluorouracil were successfully loaded into PLGA nanofiber mats by emulsion electrospinning. The natural bioactive protein gelatin (GE) was incorporated into the nanofiber mats to improve the surface properties of the materials for cell adhesion. Nanofibrous scaffolds were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, contact angle and tensile measurements. Emulsion electrospun fibers with GE had perfect hydrophilic and good mechanical property. The in vitro release test showed thedrugs released from emulsion electrospun fibers, which achieved lower burst release. The cells cytotoxicity experiment indicated that emulsion electrospun fibers were less toxic and tended to promote fibroblasts cells attachment and proliferation, which implied that the electrospun fibers had promising potential application in tissue engineering or drug delivery.
新型生物相容性聚（丙交酯-乙交酯）（PLGA）纳米纤维垫具有良好的生物相容性和良好的机械强度，可用作新型组织工程支架或理想的可控药物输送系统。疏水性和亲水性药物头孢拉定和 5-氟尿嘧啶通过乳液静电纺丝成功负载到 PLGA 纳米纤维垫中。天然生物活性蛋白明胶（GE）被掺入纳米纤维垫中，以改善材料的表面性能以利于细胞黏附。通过扫描电子显微镜、X 射线衍射、差示扫描量热法、接触角和拉伸测量对纳米纤维支架进行了表征。含有 GE 的乳液静电纺纤维具有完美的亲水性和良好的机械性能。体外释放试验表明，药物从乳液静电纺纤维中释放出来，实现了较低的突释。细胞毒性实验表明，乳液静电纺纤维的毒性较小，且趋向于促进成纤维细胞的黏附和增殖，这意味着静电纺纤维在组织工程或药物输送方面具有广阔的应用前景。
