姜黄素补充剂对肠道缺血再灌注损伤的保护作用。
Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury.
机构信息
Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey.
出版信息
Phytomedicine. 2013 Jul 15;20(10):844-8. doi: 10.1016/j.phymed.2013.03.022. Epub 2013 May 4.
The aim of this study was to investigate the effects curcumin on inflammation and oxidative stress markers in the intestinal ischemia reperfusion (IIR) injury induced rats. Rats were divided into four groups: sham (S), intestinal IR (IIR), curcumin plus sham (CS), and curcumin plus intestinal IR (CIIR). Curcumin was given 200 mg kg⁻¹ for 20 days. IIR was produced by 45 min of intestinal ischemia followed by a 120 min of reperfusion. Although interleukin-6 levels tended to increase in IIR group tumor necrosis factor-α levels were not different. Intestinal myeloperoxidase activity in CS group was lower than IIR group. In intestine and heart tissues, malondialdehyde levels in CS and CIIR groups were lower than S and IIR groups. Superoxide dismutase activity in CIIR group was higher than IIR group in intestine and lung tissues. Curcumin has a protective role against ischemia reperfusion injury.
本研究旨在探讨姜黄素对肠缺血再灌注（IIR）损伤诱导大鼠炎症和氧化应激标志物的影响。大鼠分为四组：假手术（S）组、肠缺血再灌注（IIR）组、姜黄素加假手术（CS）组和姜黄素加肠缺血再灌注（CIIR）组。姜黄素以 200mg/kg 的剂量给予 20 天。通过 45 分钟的肠缺血再灌注 120 分钟来产生 IIR。虽然 IIR 组的白细胞介素-6 水平趋于升高，但肿瘤坏死因子-α水平没有差异。CS 组的肠道髓过氧化物酶活性低于 IIR 组。在肠和心脏组织中，CS 和 CIIR 组的丙二醛水平低于 S 和 IIR 组。CIIR 组在肠和肺组织中的超氧化物歧化酶活性高于 IIR 组。姜黄素对缺血再灌注损伤具有保护作用。
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