姜黄素对人膀胱癌的抗肿瘤作用。
Antitumor effects of curcumin in human bladder cancer .
作者信息
Shi Jing, Zhang Xu, Shi Taoping, Li Hongzhao
机构信息
Department of Urology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
出版信息
Oncol Lett. 2017 Jul;14(1):1157-1161. doi: 10.3892/ol.2017.6205. Epub 2017 May 18.
Abstract
Bladder cancer is one of the major causes of cancer-associated mortality, with a high incidence. Curcumin, a polyphenol compound extracted from turmeric, has been identified to regulate tumor progression. However, the therapeutic effect of curcumin in human bladder cancer has not yet been determined. In the present study, the effects of curcumin on cell growth, apoptosis and migration of bladder cancer cell lines were evaluated using an MTT assay, a Transwell assay and flow cytometry, and the associated mechanisms were investigated using western blot analysis. Curcumin was identified to decrease the growth of T24 and 5637 cells in a dose- and time-dependent manner. The present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways . The anticancer effects of curcumin on bladder cancer cells may benefit clinical practice in the future.
摘要
膀胱癌是癌症相关死亡的主要原因之一，发病率很高。姜黄素是从姜黄中提取的一种多酚化合物，已被证实可调节肿瘤进展。然而，姜黄素对人类膀胱癌的治疗效果尚未确定。在本研究中，使用MTT法、Transwell法和流式细胞术评估了姜黄素对膀胱癌细胞系细胞生长、凋亡和迁移的影响，并使用蛋白质印迹分析研究了相关机制。结果表明，姜黄素以剂量和时间依赖性方式降低T24和5637细胞的生长。本研究证实，姜黄素能够通过抑制基质金属蛋白酶信号通路来抑制膀胱癌细胞迁移并促进其凋亡。姜黄素对膀胱癌细胞的抗癌作用可能会在未来造福临床实践。
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Am J Cancer Res. 2017 Jan 1;7(1):125-133. eCollection 2017.
2
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Onco Targets Ther. 2016 Dec 5;9:7373-7384. doi: 10.2147/OTT.S118272. eCollection 2016.
3
Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9.姜黄素通过AMPK诱导抑制NF-κB、尿激酶型纤溶酶原激活剂和基质金属蛋白酶9来抑制结肠癌细胞的侵袭。
Oncol Lett. 2016 Nov;12(5):4139-4146. doi: 10.3892/ol.2016.5148. Epub 2016 Sep 16.
4
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Oncotarget. 2015 Sep 22;6(28):25932-42. doi: 10.18632/oncotarget.4577.
5
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6
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Nanotechnology. 2015 Jan 30;26(4):045603. doi: 10.1088/0957-4484/26/4/045603. Epub 2015 Jan 6.
7
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